AT5G15830 : basic leucine-zipper 3
Query Information
Cytoscape Web will replace the contents of this div with your graph.
AGICode AT5G15830
Description basic leucine-zipper 3
Gene information
Help   
  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT5G15830 basic leucine-zipper 3 basic leucine-zipper 3, basic
leucine-zipper 3		 1 0.33 -0.33
2 AT5G19970 unknown protein; Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).		 0.87 0.31 -0.33
3 AT5G04950 nicotianamine synthase 1 ARABIDOPSIS THALIANA NICOTIANAMINE
SYNTHASE 1, nicotianamine synthase
1		 0.86 0.31 -0.32
4 AT1G02050 Chalcone and stilbene synthase family protein LESS ADHESIVE POLLEN 6 0.83 0.32 -0.33
5 AT4G37540 LOB domain-containing protein 39 LOB domain-containing protein 39 0.82 0.3 -0.32
6 AT3G05010 Protein of unknown function, transmembrane-40 -0.81 0.32 -0.32
7 AT1G13080 cytochrome P450, family 71, subfamily B, polypeptide 2 cytochrome P450, family 71,
subfamily B, polypeptide 2		 0.81 0.32 -0.31
8 AT1G53050 Protein kinase superfamily protein -0.81 0.33 -0.29
9 AT2G06530 SNF7 family protein VPS2.1 -0.81 0.32 -0.31
10 AT1G54130 RELA/SPOT homolog 3 AT-RSH3, RELA/SPOT HOMOLOG 3,
RELA/SPOT homolog 3		 -0.8 0.3 -0.35
11 AT3G43230 RING/FYVE/PHD-type zinc finger family protein -0.79 0.32 -0.32
12 AT1G24280 glucose-6-phosphate dehydrogenase 3 glucose-6-phosphate dehydrogenase
3		 0.79 0.3 -0.31
13 AT2G37580 RING/U-box superfamily protein -0.79 0.3 -0.33
14 AT1G28050 B-box type zinc finger protein with CCT domain -0.79 0.3 -0.33
15 AT1G73480 alpha/beta-Hydrolases superfamily protein -0.78 0.32 -0.31
16 AT3G18040 MAP kinase 9 MAP kinase 9 -0.78 0.32 -0.33
17 AT5G13200 GRAM domain family protein -0.78 0.34 -0.3
18 AT1G65890 acyl activating enzyme 12 acyl activating enzyme 12 -0.78 0.3 -0.3
19 AT2G17700 ACT-like protein tyrosine kinase family protein serine/threonine/tyrosine kinase 8 -0.77 0.33 -0.3
20 AT5G48370 Thioesterase/thiol ester dehydrase-isomerase superfamily
protein		 -0.77 0.31 -0.32
21 AT1G23060 BEST Arabidopsis thaliana protein match is: TPX2 (targeting
protein for Xklp2) protein family (TAIR:AT1G70950.1); Has
449 Blast hits to 419 proteins in 98 species: Archae - 0;
Bacteria - 40; Metazoa - 139; Fungi - 21; Plants - 158;
Viruses - 3; Other Eukaryotes - 88 (source: NCBI BLink).		 -0.77 0.34 -0.31
22 AT2G15620 nitrite reductase 1 ARABIDOPSIS THALIANA NITRITE
REDUCTASE, NITRITE REDUCTASE,
nitrite reductase 1		 0.77 0.31 -0.32
23 AT1G17930 Aminotransferase-like, plant mobile domain family protein -0.77 0.31 -0.31
24 AT5G49360 beta-xylosidase 1 BETA-XYLOSIDASE 1, beta-xylosidase
1		 0.77 0.3 -0.32
25 AT1G76380 DNA-binding bromodomain-containing protein -0.76 0.31 -0.31
26 AT4G36010 Pathogenesis-related thaumatin superfamily protein -0.76 0.32 -0.32
27 AT2G21620 Adenine nucleotide alpha hydrolases-like superfamily
protein		 RD2 -0.76 0.31 -0.31
28 AT2G41040 S-adenosyl-L-methionine-dependent methyltransferases
superfamily protein		 -0.76 0.32 -0.32
29 AT4G23400 plasma membrane intrinsic protein 1;5 plasma membrane intrinsic protein
1;5, PIP1D		 0.76 0.31 -0.3
30 AT3G25790 myb-like transcription factor family protein 0.76 0.31 -0.31
31 AT5G09620 Octicosapeptide/Phox/Bem1p family protein -0.76 0.31 -0.31
32 AT1G71950 Proteinase inhibitor, propeptide -0.76 0.31 -0.31
33 AT3G47550 RING/FYVE/PHD zinc finger superfamily protein -0.76 0.32 -0.33
34 AT2G43320 S-adenosyl-L-methionine-dependent methyltransferases
superfamily protein		 -0.76 0.31 -0.34
35 AT5G04250 Cysteine proteinases superfamily protein -0.76 0.31 -0.33
36 AT1G27200 Domain of unknown function (DUF23) -0.76 0.31 -0.31
37 AT3G23280 XB3 ortholog 5 in Arabidopsis thaliana XB3 ortholog 5 in Arabidopsis
thaliana		 -0.75 0.31 -0.33
38 AT2G37970 SOUL heme-binding family protein SOUL-1 -0.75 0.28 -0.31
39 AT5G52890 AT hook motif-containing protein 0.75 0.33 -0.32
40 AT3G23930 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: N-terminal protein myristoylation; LOCATED IN:
cellular_component unknown; EXPRESSED IN: hypocotyl; BEST
Arabidopsis thaliana protein match is: unknown protein
(TAIR:AT4G13540.1); Has 10639 Blast hits to 7432 proteins
in 646 species: Archae - 82; Bacteria - 826; Metazoa -
5047; Fungi - 759; Plants - 314; Viruses - 86; Other
Eukaryotes - 3525 (source: NCBI BLink).		 0.75 0.31 -0.33
41 AT3G11580 AP2/B3-like transcriptional factor family protein -0.75 0.33 -0.32
42 AT1G73080 PEP1 receptor 1 PEP1 RECEPTOR 1, PEP1 receptor 1 -0.75 0.32 -0.32
43 AT2G15320 Leucine-rich repeat (LRR) family protein -0.75 0.32 -0.31
44 AT3G62930 Thioredoxin superfamily protein 0.75 0.31 -0.32
45 AT4G22756 sterol C4-methyl oxidase 1-2 ATSMO1-2, sterol C4-methyl oxidase
1-2		 0.75 0.29 -0.31
46 AT3G16785 phospholipase D P1 PHOSPHOLIPASE D ZETA 1,
phospholipase D P1, PHOSPHOLIPASE
D ZETA1, PLDZETA1		 -0.75 0.32 -0.31
47 AT5G01700 Protein phosphatase 2C family protein 0.75 0.3 -0.33
48 AT1G76590 PLATZ transcription factor family protein -0.74 0.31 -0.31
49 AT1G74430 myb domain protein 95 ARABIDOPSIS THALIANA MYB DOMAIN
PROTEIN 95, ARABIDOPSIS THALIANA
MYB DOMAIN CONTAINING PROTEIN 66,
myb domain protein 95		 -0.74 0.34 -0.31
50 AT5G43260 chaperone protein dnaJ-related -0.74 0.31 -0.3
51 AT1G68820 Transmembrane Fragile-X-F-associated protein -0.74 0.3 -0.35
52 AT3G28007 Nodulin MtN3 family protein AtSWEET4, SWEET4 -0.74 0.29 -0.31
53 AT3G54990 Integrase-type DNA-binding superfamily protein SCHLAFMUTZE -0.74 0.3 -0.31
54 AT3G45210 Protein of unknown function, DUF584 0.74 0.31 -0.31
55 AT5G66290 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: N-terminal protein myristoylation; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 14 plant
structures; EXPRESSED DURING: 7 growth stages; Has 1807
Blast hits to 1807 proteins in 277 species: Archae - 0;
Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385;
Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).		 -0.74 0.32 -0.32
56 AT3G26020 Protein phosphatase 2A regulatory B subunit family protein -0.74 0.29 -0.33
57 AT1G45050 Ubiquitin-conjugating enzyme family protein ATUBC2-1, Arabidopsis thaliana
ubiquitin-conjugating enzyme 15		 -0.74 0.32 -0.31
58 AT1G51950 indole-3-acetic acid inducible 18 indole-3-acetic acid inducible 18 -0.74 0.31 -0.31
59 AT4G25835 P-loop containing nucleoside triphosphate hydrolases
superfamily protein		 0.74 0.34 -0.33
60 AT1G80050 adenine phosphoribosyl transferase 2 adenine phosphoribosyl transferase
2, ATAPT2, PHT1.1		 0.74 0.35 -0.33
61 AT1G12080 Vacuolar calcium-binding protein-related 0.74 0.31 -0.32
62 AT5G65010 asparagine synthetase 2 asparagine synthetase 2 0.74 0.31 -0.31
63 AT5G52660 Homeodomain-like superfamily protein -0.74 0.3 -0.31
64 AT1G68740 EXS (ERD1/XPR1/SYG1) family protein PHO1;H1 0.73 0.29 -0.31
65 AT2G22010 related to KPC1 related to KPC1 -0.73 0.3 -0.33
66 AT1G07310 Calcium-dependent lipid-binding (CaLB domain) family
protein		 -0.73 0.34 -0.31
67 AT5G41560 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
biological_process unknown; LOCATED IN: chloroplast;
EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15
growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin
ligase, Det1/DDB1-complexing (InterPro:IPR018276); Has 1807
Blast hits to 1807 proteins in 277 species: Archae - 0;
Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385;
Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).		 -0.73 0.32 -0.31
68 AT1G56300 Chaperone DnaJ-domain superfamily protein -0.73 0.31 -0.32
69 AT2G17990 BEST Arabidopsis thaliana protein match is:
kinectin-related (TAIR:AT5G66250.3); Has 7578 Blast hits to
6129 proteins in 783 species: Archae - 220; Bacteria -
1045; Metazoa - 3605; Fungi - 575; Plants - 442; Viruses -
38; Other Eukaryotes - 1653 (source: NCBI BLink).		 -0.73 0.3 -0.33
70 AT4G22570 adenine phosphoribosyl transferase 3 adenine phosphoribosyl transferase
3		 0.73 0.3 -0.31
71 AT1G79680 WALL ASSOCIATED KINASE (WAK)-LIKE 10 ATWAKL10, WALL ASSOCIATED KINASE
(WAK)-LIKE 10		 -0.73 0.31 -0.3
72 AT5G16290 VALINE-TOLERANT 1 VALINE-TOLERANT 1 -0.73 0.3 -0.31
73 AT2G32090 Lactoylglutathione lyase / glyoxalase I family protein -0.73 0.32 -0.31
74 AT1G65580 Endonuclease/exonuclease/phosphatase family protein FRAGILE FIBER3 -0.73 0.31 -0.32
75 AT3G29670 HXXXD-type acyl-transferase family protein phenolic glucoside
malonyltransferase 2		 -0.73 0.3 -0.32
76 AT3G21560 UDP-Glycosyltransferase superfamily protein UGT84A2 -0.72 0.32 -0.31
77 AT3G16800 Protein phosphatase 2C family protein -0.72 0.31 -0.3
78 AT1G26390 FAD-binding Berberine family protein -0.72 0.32 -0.32
79 AT1G68690 Protein kinase superfamily protein proline-rich extensin-like
receptor kinase 9, proline-rich
extensin-like receptor kinase 9		 -0.72 0.33 -0.3
80 AT3G08760 Protein kinase superfamily protein ATSIK -0.72 0.32 -0.33
81 AT3G46460 ubiquitin-conjugating enzyme 13 ubiquitin-conjugating enzyme 13 -0.72 0.32 -0.32
82 AT3G14050 RELA/SPOT homolog 2 RELA-SPOT HOMOLOG 2, RELA/SPOT
HOMOLOG 2, RELA/SPOT homolog 2		 -0.72 0.32 -0.3
83 AT5G49660 Leucine-rich repeat transmembrane protein kinase family
protein		 XYLEM INTERMIXED WITH PHLOEM 1 -0.72 0.32 -0.31
84 AT3G07940 Calcium-dependent ARF-type GTPase activating protein family -0.72 0.3 -0.31
85 AT5G56190 Transducin/WD40 repeat-like superfamily protein -0.72 0.31 -0.3
86 AT3G03740 BTB-POZ and MATH domain 4 BTB-POZ AND MATH DOMAIN 4, BTB-POZ
and MATH domain 4		 -0.72 0.31 -0.32
87 AT4G22980 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
biological_process unknown; LOCATED IN: chloroplast;
EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 9
growth stages; BEST Arabidopsis thaliana protein match is:
Pyridoxal phosphate (PLP)-dependent transferases
superfamily protein (TAIR:AT5G51920.1); Has 520 Blast hits
to 468 proteins in 130 species: Archae - 5; Bacteria - 23;
Metazoa - 99; Fungi - 131; Plants - 231; Viruses - 0; Other
Eukaryotes - 31 (source: NCBI BLink).		 -0.72 0.32 -0.31
88 AT3G21610 Acid phosphatase/vanadium-dependent haloperoxidase-related
protein		 -0.72 0.32 -0.32
89 AT4G17340 tonoplast intrinsic protein 2;2 DELTA-TIP2, tonoplast intrinsic
protein 2;2		 0.72 0.33 -0.32
90 AT3G44830 Lecithin:cholesterol acyltransferase family protein -0.72 0.32 -0.32
91 AT5G50100 Putative thiol-disulphide oxidoreductase DCC -0.72 0.3 -0.33
92 AT2G43430 glyoxalase 2-1 glyoxalase 2-1, GLYOXALASE II -0.72 0.31 -0.32
93 AT3G55070 LisH/CRA/RING-U-box domains-containing protein -0.71 0.29 -0.33
94 AT1G62430 CDP-diacylglycerol synthase 1 CDP-diacylglycerol synthase 1,
CDP-diacylglycerol synthase 1		 -0.71 0.32 -0.3
95 AT1G75300 NmrA-like negative transcriptional regulator family protein -0.71 0.32 -0.31
96 AT3G57090 Tetratricopeptide repeat (TPR)-like superfamily protein BIGYIN, FISSION 1A -0.71 0.35 -0.31
97 AT5G03660 Family of unknown function (DUF662) -0.71 0.31 -0.34
98 AT4G15470 Bax inhibitor-1 family protein -0.71 0.31 -0.33
99 AT3G59290 ENTH/VHS family protein -0.71 0.3 -0.34
100 AT1G28200 FH interacting protein 1 FH interacting protein 1 -0.71 0.31 -0.32
101 AT5G54130 Calcium-binding endonuclease/exonuclease/phosphatase family 0.71 0.34 -0.3
102 AT2G44380 Cysteine/Histidine-rich C1 domain family protein 0.71 0.31 -0.3
103 AT1G60390 polygalacturonase 1 polygalacturonase 1 0.71 0.31 -0.32
104 AT1G25370 Protein of unknown function (DUF1639) -0.71 0.34 -0.32
105 AT4G30790 INVOLVED IN: autophagy; EXPRESSED IN: 24 plant structures;
EXPRESSED DURING: 15 growth stages; CONTAINS InterPro
DOMAIN/s: Autophagy-related protein 17
(InterPro:IPR007240), Autophagy-related protein 11
(InterPro:IPR019460); Has 8793 Blast hits to 6268 proteins
in 570 species: Archae - 89; Bacteria - 657; Metazoa -
4844; Fungi - 808; Plants - 441; Viruses - 15; Other
Eukaryotes - 1939 (source: NCBI BLink).		 -0.71 0.31 -0.31
106 AT1G10970 zinc transporter 4 precursor ATZIP4, zinc transporter 4
precursor		 0.71 0.33 -0.31
107 AT1G32970 Subtilisin-like serine endopeptidase family protein -0.71 0.31 -0.32
108 AT3G20300 Protein of unknown function (DUF3537) -0.71 0.3 -0.33
109 AT3G21700 Ras-related small GTP-binding family protein ATSGP2, SGP2 -0.71 0.3 -0.32
110 AT3G63110 isopentenyltransferase 3 isopentenyltransferase 3,
isopentenyltransferase 3		 0.71 0.33 -0.31
111 AT1G06430 FTSH protease 8 FTSH protease 8 -0.71 0.32 -0.32
112 AT3G26230 cytochrome P450, family 71, subfamily B, polypeptide 24 cytochrome P450, family 71,
subfamily B, polypeptide 24		 0.71 0.31 -0.31
113 AT1G76350 Plant regulator RWP-RK family protein -0.71 0.33 -0.32
114 AT3G54030 Protein kinase protein with tetratricopeptide repeat domain -0.71 0.3 -0.32
115 AT3G54680 proteophosphoglycan-related -0.7 0.31 -0.31
116 AT4G35790 phospholipase D delta ARABIDOPSIS THALIANA PHOSPHOLIPASE
D DELTA, phospholipase D delta		 -0.7 0.29 -0.31
117 AT1G77770 Protein of unknown function (DUF1644) -0.7 0.31 -0.33
118 AT1G43620 UDP-Glycosyltransferase superfamily protein TRANSPARENT TESTA 15, UGT80B1 -0.7 0.31 -0.33
119 AT4G28600 no pollen germination related 2 no pollen germination related 2 -0.7 0.32 -0.3
120 AT3G24200 FAD/NAD(P)-binding oxidoreductase family protein -0.7 0.29 -0.3
121 AT3G07360 plant U-box 9 ARABIDOPSIS THALIANA PLANT U-BOX
9, plant U-box 9		 -0.7 0.29 -0.29
122 AT5G49890 chloride channel C ATCLC-C, chloride channel C -0.7 0.28 -0.3
123 AT1G48960 Adenine nucleotide alpha hydrolases-like superfamily
protein		 0.7 0.32 -0.31
124 AT1G06790 RNA polymerase Rpb7 N-terminal domain-containing protein 0.7 0.34 -0.32
125 AT3G05220 Heavy metal transport/detoxification superfamily protein -0.7 0.31 -0.32
126 AT1G78750 F-box/RNI-like superfamily protein 0.7 0.33 -0.3
127 AT5G04170 Calcium-binding EF-hand family protein -0.7 0.33 -0.32
128 AT1G78600 light-regulated zinc finger protein 1 B-box domain protein 22, DOUBLE
B-BOX 3, light-regulated zinc
finger protein 1, SALT TOLERANCE
HOMOLOG 3		 -0.7 0.31 -0.31
129 AT3G01560 Protein of unknown function (DUF1421) -0.7 0.3 -0.31
130 AT2G28250 Protein kinase superfamily protein NCRK 0.69 0.31 -0.31
131 AT3G03320 RNA-binding ASCH domain protein 0.69 0.32 -0.31
132 AT1G17250 receptor like protein 3 receptor like protein 3, receptor
like protein 3		 0.69 0.32 -0.31
133 AT3G03040 F-box/RNI-like superfamily protein 0.68 0.3 -0.34
134 AT1G30510 root FNR 2 root FNR 2, root FNR 2 0.68 0.32 -0.3
135 AT5G26200 Mitochondrial substrate carrier family protein 0.68 0.3 -0.31
136 AT1G23050 hydroxyproline-rich glycoprotein family protein 0.67 0.29 -0.32
137 AT5G58770 Undecaprenyl pyrophosphate synthetase family protein 0.67 0.29 -0.31
138 AT1G78090 trehalose-6-phosphate phosphatase Arabidopsis thaliana
trehalose-6-phosphate phosphatase
B, trehalose-6-phosphate
phosphatase B		 0.67 0.33 -0.3
139 AT3G49940 LOB domain-containing protein 38 LOB domain-containing protein 38 0.67 0.32 -0.3
140 AT3G23630 isopentenyltransferase 7 ARABIDOPSIS THALIANA
ISOPENTENYLTRANSFERASE 7,
isopentenyltransferase 7		 0.67 0.33 -0.33
141 AT5G66240 Transducin/WD40 repeat-like superfamily protein 0.67 0.31 -0.3
142 AT5G07820 Plant calmodulin-binding protein-related 0.67 0.28 -0.32
143 AT4G24260 glycosyl hydrolase 9A3 glycosyl hydrolase 9A3, glycosyl
hydrolase 9A3, KOR3		 0.67 0.33 -0.3
144 AT1G22500 RING/U-box superfamily protein Arabidopsis thaliana Arabidopsis
toxicos en levadura 15,
Arabidopsis toxicos en levadura 15		 0.67 0.32 -0.35
145 AT1G49370 pseudogene, similar to OSJNBa0072F16.8, blastp match of 42%
identity and 6.6e-73 P-value to
GP|21739229|emb|CAD40984.1||AL606460 OSJNBa0072F16.8 {Oryza
sativa (japonica cultivar-group)}		 0.66 0.31 -0.32
146 AT3G28960 Transmembrane amino acid transporter family protein 0.66 0.29 -0.33
147 AT3G16650 Transducin/WD40 repeat-like superfamily protein 0.66 0.31 -0.32
148 AT1G03620 ELMO/CED-12 family protein 0.66 0.3 -0.33
149 AT4G19420 Pectinacetylesterase family protein 0.66 0.32 -0.33
150 AT1G50110 D-aminoacid aminotransferase-like PLP-dependent enzymes
superfamily protein		 0.66 0.3 -0.31
151 AT1G71790 Subunits of heterodimeric actin filament capping protein
Capz superfamily		 0.66 0.33 -0.31
152 AT1G60960 iron regulated transporter 3 IRON REGULATED TRANSPORTER 3, iron
regulated transporter 3		 0.66 0.32 -0.33
153 AT3G02910 AIG2-like (avirulence induced gene) family protein 0.66 0.31 -0.32
154 AT1G19900 glyoxal oxidase-related protein 0.66 0.32 -0.31
155 AT1G37130 nitrate reductase 2 ARABIDOPSIS NITRATE REDUCTASE 2,
B29, CHLORATE RESISTANT 3, nitrate
reductase 2, NIA2-1, NITRATE
REDUCTASE, NITRATE REDUCTASE 2		 0.65 0.31 -0.31
156 AT4G27730 oligopeptide transporter 1 ARABIDOPSIS THALIANA OLIGOPEPTIDE
TRANSPORTER 6, oligopeptide
transporter 1		 0.65 0.34 -0.33
157 AT3G01690 alpha/beta-Hydrolases superfamily protein 0.65 0.31 -0.33
158 AT1G73640 RAB GTPase homolog A6A RAB GTPase homolog A6A, RAB GTPase
homolog A6A		 0.65 0.29 -0.31
159 AT4G36350 purple acid phosphatase 25 ARABIDOPSIS THALIANA PURPLE ACID
PHOSPHATASE 25, purple acid
phosphatase 25		 0.65 0.32 -0.32
160 AT1G49160 Protein kinase superfamily protein WNK7 0.65 0.31 -0.33
161 AT2G24762 glutamine dumper 4 glutamine dumper 4, glutamine
dumper 4		 0.65 0.31 -0.32
162 AT4G22790 MATE efflux family protein 0.65 0.31 -0.31
163 AT1G78320 glutathione S-transferase TAU 23 glutathione S-transferase TAU 23,
glutathione S-transferase TAU 23		 0.65 0.33 -0.3
164 AT5G65350 histone 3 11 histone 3 11 0.65 0.33 -0.3
165 AT5G03840 PEBP (phosphatidylethanolamine-binding protein) family
protein		 TERMINAL FLOWER 1, TERMINAL FLOWER
1		 0.65 0.32 -0.31
Metabolite information
Help   
  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
166 C0158 MST_1480.5 - - - -0.73 0.48 -0.47
167 C0252 Threonic acid D,L-Threonic acid L-Threonate ascorbic acid degradation -0.7 0.46 -0.43 C0252