AT5G55310 : TOPOISOMERASE 1
Query Information
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AGICode AT5G55310
Description DNA topoisomerase 1 beta
Gene information
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  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT5G55310 DNA topoisomerase 1 beta TOPOISOMERASE 1, DNA topoisomerase
1 beta		 1 0.32 -0.31
2 AT1G05790 lipase class 3 family protein 0.84 0.3 -0.31
3 AT4G28050 tetraspanin7 tetraspanin7 -0.77 0.32 -0.32
4 AT2G41790 Insulinase (Peptidase family M16) family protein 0.77 0.3 -0.33
5 AT5G42870 phosphatidic acid phosphohydrolase 2 PHOSPHATIDIC ACID PHOSPHOHYDROLASE
2, phosphatidic acid
phosphohydrolase 2		 0.77 0.32 -0.32
6 AT2G22910 N-acetyl-l-glutamate synthase 1 N-acetyl-l-glutamate synthase 1 0.76 0.33 -0.33
7 AT5G16210 HEAT repeat-containing protein 0.76 0.31 -0.32
8 AT1G09230 RNA-binding (RRM/RBD/RNP motifs) family protein 0.75 0.34 -0.32
9 AT3G10730 SAD1/UNC-84 domain protein 2 ARABIDOPSIS SAD1/UNC-84 DOMAIN
PROTEIN 2, SAD1/UNC-84 domain
protein 2		 -0.74 0.3 -0.31
10 AT1G24460 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 23 plant
structures; EXPRESSED DURING: 14 growth stages; BEST
Arabidopsis thaliana protein match is: unknown protein
(TAIR:AT4G31570.1); Has 181008 Blast hits to 85359 proteins
in 3551 species: Archae - 3290; Bacteria - 48304; Metazoa -
70793; Fungi - 13943; Plants - 10118; Viruses - 785; Other
Eukaryotes - 33775 (source: NCBI BLink).		 TGN-localized SYP41 interacting
protein		 0.74 0.3 -0.33
11 AT4G30130 Protein of unknown function (DUF630 and DUF632) -0.73 0.33 -0.3
12 AT3G13674 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
chloroplast; EXPRESSED IN: 17 plant structures; EXPRESSED
DURING: 11 growth stages; BEST Arabidopsis thaliana protein
match is: unknown protein (TAIR:AT1G55205.1); Has 76 Blast
hits to 76 proteins in 10 species: Archae - 0; Bacteria -
0; Metazoa - 0; Fungi - 0; Plants - 76; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 -0.73 0.34 -0.32
13 AT1G09630 RAB GTPase 11C ARABIDOPSIS RAB GTPASE A2A, RAB
GTPase 11C, ARABIDOPSIS RAB GTPASE
A2A, RAB GTPASE A2A, RAB GTPase
11C		 -0.73 0.32 -0.32
14 AT2G39900 GATA type zinc finger transcription factor family protein WLIM2a -0.73 0.31 -0.33
15 AT2G20300 Protein kinase superfamily protein Abnormal Leaf Shape 2 -0.72 0.32 -0.33
16 AT4G02550 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT4G02210.2); Has 370 Blast hits
to 300 proteins in 18 species: Archae - 0; Bacteria - 0;
Metazoa - 0; Fungi - 10; Plants - 354; Viruses - 0; Other
Eukaryotes - 6 (source: NCBI BLink).		 0.72 0.32 -0.31
17 AT1G16010 magnesium transporter 2 AtMGT2, AtMRS2-1, magnesium
transporter 2, MRS2-1		 0.71 0.34 -0.33
18 AT1G47200 WPP domain protein 2 WPP domain protein 2 -0.71 0.31 -0.32
19 AT1G48780 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT3G18300.1); Has 89 Blast hits
to 89 proteins in 11 species: Archae - 0; Bacteria - 2;
Metazoa - 0; Fungi - 0; Plants - 86; Viruses - 0; Other
Eukaryotes - 1 (source: NCBI BLink).		 -0.71 0.3 -0.3
20 AT5G61910 DCD (Development and Cell Death) domain protein 0.7 0.31 -0.33
21 AT3G18780 actin 2 actin 2, DEFORMED ROOT HAIRS 1,
ENHANCER OF LRX1 2, FRIZZY AND
KINKED SHOOTS 2, LIGHT
STRESS-REGULATED 2		 -0.7 0.31 -0.32
22 AT1G31600 RNA-binding (RRM/RBD/RNP motifs) family protein Arabidopsis thaliana tRNA
methyltransferase 9, tRNA
methyltransferase 9		 0.7 0.31 -0.31
23 AT5G10940 transducin family protein / WD-40 repeat family protein ALTERED SEED GERMINATION 2 0.7 0.31 -0.33
24 AT5G26240 chloride channel D ATCLC-D, chloride channel D 0.69 0.3 -0.33
25 AT2G17975 zinc finger (Ran-binding) family protein 0.69 0.31 -0.31
26 AT3G28890 receptor like protein 43 receptor like protein 43, receptor
like protein 43		 0.69 0.32 -0.31
27 AT4G14960 Tubulin/FtsZ family protein TUA6 -0.69 0.32 -0.33
28 AT1G23550 similar to RCD one 2 similar to RCD one 2 0.69 0.31 -0.34
29 AT3G63150 MIRO-related GTP-ase 2 CALCIUM BINDING GTP-ASE,
MIRO-related GTP-ase 2		 0.69 0.31 -0.33
30 AT2G23110 Late embryogenesis abundant protein, group 6 0.69 0.32 -0.33
31 AT2G39880 myb domain protein 25 myb domain protein 25, myb domain
protein 25		 -0.68 0.32 -0.3
32 AT4G12760 unknown protein; Has 30201 Blast hits to 17322 proteins in
780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338;
Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes
- 2996 (source: NCBI BLink).		 0.68 0.3 -0.32
33 AT5G06100 myb domain protein 33 ATMYB33, myb domain protein 33 0.68 0.31 -0.3
34 AT1G18160 Protein kinase superfamily protein 0.68 0.34 -0.31
35 AT4G34140 D111/G-patch domain-containing protein 0.68 0.3 -0.32
36 AT2G04780 FASCICLIN-like arabinoogalactan 7 FASCICLIN-like arabinoogalactan 7 -0.68 0.3 -0.32
37 AT3G09560 Lipin family protein PHOSPHATIDIC ACID PHOSPHOHYDROLASE
1, PHOSPHATIDIC ACID
PHOSPHOHYDROLASE 1		 0.67 0.31 -0.32
38 AT1G36510 Nucleic acid-binding proteins superfamily 0.67 0.32 -0.33
39 AT2G46930 Pectinacetylesterase family protein -0.67 0.31 -0.33
40 AT2G42160 zinc finger (ubiquitin-hydrolase) domain-containing protein BRAP2 RING ZnF UBP
domain-containing protein 1		 0.67 0.33 -0.31
41 AT5G11700 LOCATED IN: vacuole; EXPRESSED IN: 24 plant structures;
EXPRESSED DURING: 13 growth stages; BEST Arabidopsis
thaliana protein match is: glycine-rich protein
(TAIR:AT4G32920.3); Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).		 0.67 0.31 -0.36
42 AT2G15860 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 24 plant
structures; EXPRESSED DURING: 13 growth stages; Has 30201
Blast hits to 17322 proteins in 780 species: Archae - 12;
Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants -
5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI
BLink).		 -0.67 0.34 -0.31
43 AT5G46340 O-acetyltransferase family protein REDUCED WALL ACETYLATION 1 0.67 0.31 -0.31
44 AT3G43720 Bifunctional inhibitor/lipid-transfer protein/seed storage
2S albumin superfamily protein		 -0.67 0.32 -0.33
45 AT3G46220 unknown protein; CONTAINS InterPro DOMAIN/s: Protein of
unknown function DUF2042 (InterPro:IPR018611); Has 559
Blast hits to 533 proteins in 154 species: Archae - 3;
Bacteria - 32; Metazoa - 305; Fungi - 42; Plants - 50;
Viruses - 3; Other Eukaryotes - 124 (source: NCBI BLink).		 0.67 0.3 -0.33
46 AT3G55005 tonneau 1b (TON1b) tonneau 1b -0.66 0.34 -0.28
47 AT1G24706 THO2 AtTHO2, EMBRYO DEFECTIVE 2793,
THO2		 0.66 0.3 -0.32
48 AT1G04120 multidrug resistance-associated protein 5 ATP-binding cassette C5,
Arabidopsis thaliana ATP-binding
cassette C5, multidrug
resistance-associated protein 5,
MULTIDRUG RESISTANCE PROTEIN 5,
multidrug resistance-associated
protein 5		 0.66 0.33 -0.33
49 AT3G22460 O-acetylserine (thiol) lyase (OAS-TL) isoform A2 O-acetylserine (thiol) lyase
(OAS-TL) isoform A2		 0.66 0.34 -0.31
50 AT3G07010 Pectin lyase-like superfamily protein -0.66 0.31 -0.33
51 ATMG00400 hypothetical protein ORF157 0.66 0.31 -0.3
52 AT1G45160 Protein kinase superfamily protein 0.66 0.31 -0.31
53 AT2G25730 unknown protein; Has 157 Blast hits to 144 proteins in 62
species: Archae - 0; Bacteria - 0; Metazoa - 101; Fungi -
0; Plants - 35; Viruses - 0; Other Eukaryotes - 21 (source:
NCBI BLink).		 0.66 0.29 -0.29
54 AT2G46560 transducin family protein / WD-40 repeat family protein 0.66 0.33 -0.32
55 AT3G12610 Leucine-rich repeat (LRR) family protein DNA-DAMAGE REPAIR/TOLERATION 100 -0.66 0.32 -0.32
56 AT3G24180 Beta-glucosidase, GBA2 type family protein 0.66 0.32 -0.31
57 AT4G13780 methionine--tRNA ligase, putative / methionyl-tRNA
synthetase, putative / MetRS, putative		 0.66 0.3 -0.33
58 AT1G01040 dicer-like 1 ABNORMAL SUSPENSOR 1, DICER-LIKE
1, CARPEL FACTORY, dicer-like 1,
EMBRYO DEFECTIVE 60, EMBRYO
DEFECTIVE 76, SHORT INTEGUMENTS 1,
SUSPENSOR 1		 0.66 0.32 -0.31
59 AT1G56720 Protein kinase superfamily protein -0.66 0.34 -0.34
60 AT5G01620 TRICHOME BIREFRINGENCE-LIKE 35 TRICHOME BIREFRINGENCE-LIKE 35 -0.66 0.31 -0.31
61 AT2G37650 GRAS family transcription factor 0.66 0.3 -0.32
62 AT1G11610 cytochrome P450, family 71, subfamily A, polypeptide 18 cytochrome P450, family 71,
subfamily A, polypeptide 18		 0.66 0.31 -0.31
63 AT3G27810 myb domain protein 21 myb domain protein 21, ARABIDOPSIS
THALIANA MYB DOMAIN PROTEIN 3,
myb domain protein 21		 0.65 0.31 -0.32
64 AT5G37890 Protein with RING/U-box and TRAF-like domains -0.65 0.3 -0.29
65 AT1G54260 winged-helix DNA-binding transcription factor family
protein		 0.65 0.31 -0.31
66 AT3G57860 UV-B-insensitive 4-like GIGAS CELL 1, OMISSION OF SECOND
DIVISION, UV-B-insensitive 4-like		 -0.65 0.32 -0.32
67 AT5G37370 PRP38 family protein ATSRL1 0.65 0.33 -0.3
68 AT3G05100 S-adenosyl-L-methionine-dependent methyltransferases
superfamily protein		 -0.65 0.3 -0.32
69 AT4G17190 farnesyl diphosphate synthase 2 farnesyl diphosphate synthase 2 -0.65 0.33 -0.29
70 AT5G06960 OCS-element binding factor 5 OCS-element binding factor 5,
TGACG MOTIF-BINDING FACTOR 5		 0.65 0.32 -0.32
71 AT4G00800 transducin family protein / WD-40 repeat family protein SETH5 0.65 0.32 -0.31
72 AT1G12070 Immunoglobulin E-set superfamily protein -0.65 0.33 -0.32
73 AT4G12690 Plant protein of unknown function (DUF868) -0.65 0.31 -0.3
74 AT1G61420 S-locus lectin protein kinase family protein 0.64 0.32 -0.31
75 AT2G30620 winged-helix DNA-binding transcription factor family
protein		 -0.64 0.31 -0.31
76 AT4G39160 Homeodomain-like superfamily protein 0.64 0.34 -0.31
77 AT3G56800 calmodulin 3 CALMODULIN 3, calmodulin 3 -0.64 0.3 -0.32
78 AT3G01320 SIN3-like 1 SIN3-like 1 0.64 0.34 -0.34
79 AT2G41690 heat shock transcription factor B3 heat shock transcription factor
B3, HEAT SHOCK TRANSCRIPTION
FACTOR B3, heat shock
transcription factor B3		 0.64 0.32 -0.34
80 AT1G22790 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN: plasma
membrane; EXPRESSED IN: 22 plant structures; EXPRESSED
DURING: 13 growth stages; BEST Arabidopsis thaliana protein
match is: unknown protein (TAIR:AT1G34010.1); Has 67 Blast
hits to 67 proteins in 12 species: Archae - 0; Bacteria -
0; Metazoa - 0; Fungi - 0; Plants - 67; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 -0.64 0.33 -0.32
81 AT1G10630 ADP-ribosylation factor A1F ADP-ribosylation factor A1F,
ADP-ribosylation factor A1F		 -0.64 0.3 -0.34
82 AT5G41330 BTB/POZ domain with WD40/YVTN repeat-like protein 0.63 0.29 -0.31
83 AT1G04500 CCT motif family protein 0.63 0.32 -0.3
84 AT4G38680 glycine rich protein 2 ARABIDOPSIS THALIANA COLD SHOCK
PROTEIN 2, COLD SHOCK DOMAIN
PROTEIN 2, COLD SHOCK PROTEIN 2,
glycine rich protein 2		 -0.63 0.31 -0.29
85 AT4G36980 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
biological_process unknown; EXPRESSED IN: 23 plant
structures; EXPRESSED DURING: 13 growth stages; CONTAINS
InterPro DOMAIN/s: Splicing factor, suppressor of white
apricot (InterPro:IPR019147); Has 7672 Blast hits to 5479
proteins in 321 species: Archae - 0; Bacteria - 89; Metazoa
- 5155; Fungi - 712; Plants - 341; Viruses - 39; Other
Eukaryotes - 1336 (source: NCBI BLink).		 0.63 0.3 -0.31
86 AT5G02630 Lung seven transmembrane receptor family protein 0.63 0.34 -0.3
87 AT3G05020 acyl carrier protein 1 ACYL CARRIER PROTEIN, acyl carrier
protein 1		 -0.63 0.33 -0.31
88 AT5G50000 Protein kinase superfamily protein -0.63 0.31 -0.29
89 AT3G46030 Histone superfamily protein HTB11 -0.63 0.32 -0.33
90 AT4G28180 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: N-terminal protein myristoylation; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 15 plant
structures; EXPRESSED DURING: 8 growth stages; Has 1508
Blast hits to 1315 proteins in 223 species: Archae - 4;
Bacteria - 127; Metazoa - 687; Fungi - 310; Plants - 142;
Viruses - 28; Other Eukaryotes - 210 (source: NCBI BLink).		 -0.63 0.31 -0.31
91 AT2G27900 CONTAINS InterPro DOMAIN/s: Protein of unknown function
DUF2451, C-terminal (InterPro:IPR019514), Vacuolar protein
sorting-associated protein 54 (InterPro:IPR019515); Has 316
Blast hits to 252 proteins in 92 species: Archae - 0;
Bacteria - 2; Metazoa - 200; Fungi - 2; Plants - 68;
Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).		 0.63 0.31 -0.32
92 AT4G35930 F-box family protein -0.62 0.34 -0.29
93 AT5G01460 LMBR1-like membrane protein -0.62 0.33 -0.3
94 AT2G27970 CDK-subunit 2 CDK-subunit 2 -0.62 0.34 -0.33
95 AT4G02500 UDP-xylosyltransferase 2 ARABIDOPSIS THALIANA
UDP-XYLOSYLTRANSFERASE 2,
UDP-xylosyltransferase 2, XYG
XYLOSYLTRANSFERASE 2		 -0.62 0.31 -0.3
96 AT1G78150 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT1G35780.1); Has 152 Blast hits
to 146 proteins in 18 species: Archae - 0; Bacteria - 0;
Metazoa - 1; Fungi - 2; Plants - 149; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 -0.62 0.32 -0.32
97 AT1G75840 RAC-like GTP binding protein 5 RAC-like GTP binding protein 5,
ARABIDOPSIS THALIANA
GERANYLGERANYLATED PROTEIN 3,
RHO-LIKE GTP BINDING PROTEIN 4,
RHO-LIKE GTP BINDING PROTEIN 4		 -0.61 0.3 -0.32
98 AT2G22270 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT4G39860.2); Has 247 Blast hits
to 231 proteins in 42 species: Archae - 0; Bacteria - 17;
Metazoa - 14; Fungi - 5; Plants - 145; Viruses - 0; Other
Eukaryotes - 66 (source: NCBI BLink).		 -0.61 0.32 -0.33
99 AT3G03160 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
intracellular protein transport; LOCATED IN: endomembrane
system, integral to membrane, endoplasmic reticulum;
EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15
growth stages; CONTAINS InterPro DOMAIN/s: B-cell
receptor-associated 31-like (InterPro:IPR008417); BEST
Arabidopsis thaliana protein match is: unknown protein
(TAIR:AT5G17190.1); Has 102 Blast hits to 102 proteins in
17 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi -
0; Plants - 102; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.61 0.32 -0.32
100 AT3G08910 DNAJ heat shock family protein -0.61 0.31 -0.33
101 AT3G10700 galacturonic acid kinase galacturonic acid kinase -0.61 0.32 -0.31
102 AT1G43190 polypyrimidine tract-binding protein 3 polypyrimidine tract-binding
protein 3		 -0.61 0.32 -0.29
Metabolite information
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  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
103 C0105 Glutathione disulfide - Glutathione disulfide sulfate reduction II (assimilatory),
selenate reduction,
glutathione redox reactions I,
ascorbate glutathione cycle,
glutathione redox reactions II 		0.83 0.44 -0.47 C0105
104 C0228 Ribose-5-phosphate D-Ribose-5-phosphate D-Ribose-5-phosphate PRPP biosynthesis I,
Calvin-Benson-Bassham cycle,
trans-zeatin biosynthesis,
pentose phosphate pathway (non-oxidative branch),
pyridine nucleotide cycling (plants),
Rubisco shunt,
ribose degradation,
pyridoxal 5'-phosphate biosynthesis II 		-0.76 0.46 -0.45 C0228
105 C0145 Maltotetraose - Maltotetraose starch degradation II 0.74 0.45 -0.46 C0145
106 C0136 Lactic acid D,L-Lactic acid Lactate pyruvate fermentation to lactate -0.72 0.45 -0.46 C0136
107 C0107 Glycine - Glycine 5-aminoimidazole ribonucleotide biosynthesis I,
gamma-glutamyl cycle,
folate polyglutamylation,
gamma-glutamyl cycle (plant pathway),
glutathione biosynthesis,
glutathione-mediated detoxification II,
folate transformations II,
indole glucosinolate breakdown (active in intact plant cell),
glycine cleavage complex,
camalexin biosynthesis,
thiamine biosynthesis II,
tRNA charging,
glycine biosynthesis,
glutathione degradation,
photorespiration 		0.63 0.44 -0.42 C0107
108 C0187 Neoeriocitrin - - - -0.61 0.45 -0.45