C0068 : Citric acid
Query Information
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ID C0068
Compound name Citric acid
External link   http://pmn.plantcyc.org/ARA/NEW-IMAGE?type=COMPOUND&object=CIT
Pathway Information acetyl-CoA biosynthesis (from citrate),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
glutamine biosynthesis III,
glyoxylate cycle
Gene information
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  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT5G46760 Basic helix-loop-helix (bHLH) DNA-binding family protein MYC3 0.72 0.32 -0.32
2 AT5G47600 HSP20-like chaperones superfamily protein -0.69 0.3 -0.33
3 AT3G52170 DNA binding -0.68 0.32 -0.29
4 AT4G35090 catalase 2 catalase 2 -0.65 0.33 -0.33
5 AT5G51720 2 iron, 2 sulfur cluster binding -0.65 0.32 -0.31
6 AT2G05920 Subtilase family protein -0.64 0.3 -0.3
7 AT3G45620 Transducin/WD40 repeat-like superfamily protein 0.64 0.31 -0.32
8 AT5G42660 Protein of unknown function (DUF616) 0.62 0.33 -0.33
9 AT4G17480 alpha/beta-Hydrolases superfamily protein 0.62 0.33 -0.33
10 AT2G21800 essential meiotic endonuclease 1A essential meiotic endonuclease 1A,
EME1A, essential meiotic
endonuclease 1A		 -0.61 0.31 -0.31
11 AT2G40070 BEST Arabidopsis thaliana protein match is: proline-rich
family protein (TAIR:AT3G09000.1); Has 35333 Blast hits to
34131 proteins in 2444 species: Archae - 798; Bacteria -
22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses -
0; Other Eukaryotes - 9610 (source: NCBI BLink).		 -0.61 0.32 -0.31
12 AT3G61160 Protein kinase superfamily protein -0.6 0.3 -0.32
13 AT5G14380 arabinogalactan protein 6 arabinogalactan protein 6 0.6 0.3 -0.29
14 AT2G30540 Thioredoxin superfamily protein 0.6 0.33 -0.3
15 AT2G40300 ferritin 4 ferritin 4, ferritin 4 -0.6 0.32 -0.32
16 AT1G55915 zinc ion binding -0.59 0.31 -0.32
17 AT5G55370 MBOAT (membrane bound O-acyl transferase) family protein -0.59 0.33 -0.31
18 AT4G18550 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana DAD1-like
seeding establishment-related
lipase, DAD1-like seeding
establishment-related lipase		 -0.59 0.32 -0.31
19 AT2G45840 Arabidopsis thaliana protein of unknown function (DUF821) 0.58 0.34 -0.32
20 AT5G64490 ARM repeat superfamily protein -0.58 0.32 -0.32
21 AT5G07740 actin binding -0.58 0.3 -0.31
22 AT4G15210 beta-amylase 5 AT-BETA-AMY, ARABIDOPSIS THALIANA
BETA-AMYLASE, beta-amylase 5,
BMY1, REDUCED BETA AMYLASE 1		 0.56 0.35 -0.32
23 AT1G33080 MATE efflux family protein -0.56 0.3 -0.32
24 AT3G25190 Vacuolar iron transporter (VIT) family protein -0.56 0.32 -0.33
25 AT5G44750 DNA-directed DNA polymerases ARABIDOPSIS THALIANA HOMOLOG OF
REVERSIONLESS 1, REV1		 -0.55 0.32 -0.33
26 AT4G32120 Galactosyltransferase family protein -0.55 0.31 -0.31
27 AT5G55670 RNA-binding (RRM/RBD/RNP motifs) family protein -0.54 0.33 -0.32
28 AT1G69560 myb domain protein 105 MYB DOMAIN PROTEIN 105, LATERAL
ORGAN FUSION 2, myb domain protein
105		 0.54 0.32 -0.31
29 AT5G16505 transposable element gene -0.54 0.32 -0.35
30 AT2G32440 ent-kaurenoic acid hydroxylase 2 ARABIDOPSIS ENT-KAURENOIC ACID
HYDROXYLASE 2, CYP88A4,
ent-kaurenoic acid hydroxylase 2		 -0.53 0.32 -0.34
31 AT2G31080 transposable element gene -0.53 0.32 -0.31
32 AT4G38210 expansin A20 ATEXP20, expansin A20, ATHEXP
ALPHA 1.23, EXPANSIN 20, expansin
A20		 -0.53 0.31 -0.32
33 AT3G21090 ABC-2 type transporter family protein ATP-binding cassette G15 -0.53 0.3 -0.3
34 AT1G63690 SIGNAL PEPTIDE PEPTIDASE-LIKE 2 SIGNAL PEPTIDE PEPTIDASE-LIKE 2,
SIGNAL PEPTIDE PEPTIDASE-LIKE 2		 -0.53 0.32 -0.29
35 AT1G12830 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 23 plant
structures; EXPRESSED DURING: 13 growth stages; Has 39778
Blast hits to 22088 proteins in 1060 species: Archae - 152;
Bacteria - 6161; Metazoa - 14109; Fungi - 6144; Plants -
2156; Viruses - 601; Other Eukaryotes - 10455 (source: NCBI
BLink).		 -0.53 0.3 -0.31
36 AT2G17160 Interleukin-1 receptor-associated kinase 4 protein -0.52 0.33 -0.33
37 AT3G02440 TRICHOME BIREFRINGENCE-LIKE 20 TRICHOME BIREFRINGENCE-LIKE 20 -0.52 0.31 -0.29
38 AT1G37057 transposable element gene -0.52 0.34 -0.32
39 AT3G48150 anaphase-promoting complex subunit 8 anaphase-promoting complex subunit
8, CDC23		 -0.52 0.32 -0.33
40 AT1G13630 Tetratricopeptide repeat (TPR)-like superfamily protein -0.52 0.3 -0.31
41 AT2G41650 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED
DURING: 13 growth stages; Has 3 Blast hits to 3 proteins in
1 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi -
0; Plants - 3; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.52 0.35 -0.32
42 AT3G42640 H(+)-ATPase 8 H(+)-ATPase 8, H(+)-ATPase 8 -0.51 0.29 -0.3
43 AT1G31360 RECQ helicase L2 ARABIDOPSIS THALIANA RECQ 2,
MED34, RECQ helicase L2		 -0.51 0.32 -0.31
44 AT1G12520 copper chaperone for SOD1 copper chaperone for SOD1, copper
chaperone for SOD1		 -0.51 0.33 -0.32
45 AT5G19090 Heavy metal transport/detoxification superfamily protein -0.51 0.31 -0.34
46 AT5G28290 NIMA-related kinase 3 NIMA-related kinase 3,
NIMA-related kinase 3		 -0.5 0.34 -0.32
47 AT2G18070 unknown protein; BEST Arabidopsis thaliana protein match
is: Protein of unknown function DUF2359, transmembrane
(TAIR:AT1G23170.2); Has 27 Blast hits to 27 proteins in 2
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 27; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.5 0.32 -0.3
48 AT1G31100 transposable element gene -0.5 0.32 -0.31
Metabolite information
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  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
49 C0068 Citric acid - Citrate acetyl-CoA biosynthesis (from citrate),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
glutamine biosynthesis III,
glyoxylate cycle 		1 0.3 -0.33 C0068
50 C0026 2-Hydroxyisobutyric acid - - β oxidation 0.89 0.46 -0.45
51 C0091 Fructose-1,6-bisphosphate D-Fructose-1,6-bisphosphate Fructose-1,6-bisphosphate gluconeogenesis I,
Calvin-Benson-Bassham cycle,
glycolysis IV (plant cytosol),
glycolysis I,
CA1P biosynthesis,
sucrose biosynthesis I 		0.83 0.48 -0.46 C0091
52 C0027 2-Oxoglutaric acid - α-Ketoglutarate gibberellin biosynthesis III (early C-13 hydroxylation),
leucopelargonidin and leucocyanidin biosynthesis,
aspartate degradation II,
ornithine biosynthesis,
isoleucine biosynthesis I (from threonine),
pantothenate biosynthesis,
phenylalanine degradation III,
flavonol biosynthesis,
lysine biosynthesis VI,
luteolin biosynthesis,
ammonia assimilation cycle II,
serine biosynthesis,
flavonoid biosynthesis,
glutamate biosynthesis V,
aspartate biosynthesis,
glutamate degradation I,
gibberellin inactivation I (2beta-hydroxylation),
alanine degradation III,
photorespiration,
valine biosynthesis,
glycine biosynthesis,
arginine biosynthesis II (acetyl cycle),
arginine degradation I (arginase pathway),
gibberellin biosynthesis II (early C-3 hydroxylation),
leucine biosynthesis,
glutamate biosynthesis IV,
tyrosine biosynthesis II,
proline biosynthesis III,
citrulline biosynthesis,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
L-Ndelta-acetylornithine biosynthesis,
isoleucine degradation I,
alanine biosynthesis II,
tyrosine biosynthesis I,
TCA cycle variation III (eukaryotic),
leucine degradation I,
alanine degradation II (to D-lactate),
TCA cycle variation V (plant),
arginine degradation VI (arginase 2 pathway),
valine degradation I,
gibberellin biosynthesis I (non C-3, non C-13 hydroxylation),
1,4-dihydroxy-2-naphthoate biosynthesis II (plants),
2-ketoglutarate dehydrogenase complex,
glutamate degradation IV,
tyrosine degradation I,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
IAA biosynthesis I,
phenylalanine biosynthesis II,
lysine degradation II,
scopoletin biosynthesis,
4-hydroxyphenylpyruvate biosynthesis,
histidine biosynthesis,
glutamine biosynthesis III,
leucodelphinidin biosynthesis 		0.82 0.44 -0.46 C0027
53 C0243 Succinic acid - Succinate flavonol biosynthesis,
glyoxylate cycle,
gibberellin biosynthesis III (early C-13 hydroxylation),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
aerobic respiration (alternative oxidase pathway),
gibberellin inactivation I (2beta-hydroxylation),
4-aminobutyrate degradation IV,
luteolin biosynthesis,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
leucodelphinidin biosynthesis,
glutamate degradation IV,
gibberellin biosynthesis I (non C-3, non C-13 hydroxylation),
succinate + a ubiquinone -> a ubiquinol + fumarate,
gibberellin biosynthesis II (early C-3 hydroxylation),
flavonoid biosynthesis,
superpathway of glyoxylate cycle and fatty acid degradation,
aerobic respiration (cytochrome c),
leucopelargonidin and leucocyanidin biosynthesis,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
scopoletin biosynthesis 		0.77 0.3 -0.32 C0243
54 C0262 UDP-glucuronic acid - UDP-D-glucuronate xylan biosynthesis,
UDP-D-glucuronate biosynthesis (from myo-inositol),
UDP-D-galacturonate biosynthesis I (from UDP-D-glucuronate),
UDP-D-apiose biosynthesis (from UDP-D-glucuronate),
galactose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis 		0.76 0.44 -0.41 C0262
55 C0158 MST_1480.5 - - - 0.76 0.45 -0.47
56 C0075 dGDP - dGDP purine nucleotide metabolism (phosphotransfer and nucleotide modification) 0.72 0.45 -0.43 C0075
57 C0241 Stigmasterol 3-O-β-D-glucoside - Stigmasterol 3-O-β-D-glucoside - 0.71 0.5 -0.48 C0241
58 C0088 FAD - FAD cytokinins degradation,
lysine degradation II,
valine degradation I,
isoleucine degradation I,
flavin biosynthesis I (bacteria and plants) 		0.71 0.44 -0.44 C0088
59 C0184 MST_3110.4 - - - 0.71 0.45 -0.46
60 C0130 Kaempferol-3-O-α-rhamnopyranosyl(1,2)-β-glucopyranoside-7-O-α-rhamnopyranoside Kaempferol-3-O-α-L-rhamnopyranosyl(1,2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside - 0.69 0.45 -0.43
61 C0193 Pantothenic acid D,L-Pantothenic acid Pantothenate pantothenate biosynthesis 0.69 0.45 -0.46 C0193
62 C0009 myo-Inositol - myo-Inositol stachyose biosynthesis,
UDP-D-glucuronate biosynthesis (from myo-inositol),
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza),
D-myo-inositol (1,4,5)-trisphosphate degradation,
galactosylcyclitol biosynthesis,
D-myo-inositol (1,4,5)-trisphosphate biosynthesis,
phytate degradation I,
myo-inositol biosynthesis,
ajugose biosynthesis I (galactinol-dependent),
phospholipid biosynthesis II 		0.69 0.46 -0.44 C0009
63 C0175 MST_2379.9 - - - 0.68 0.45 -0.43
64 C0087 Erythrose-4-phosphate D-Erythrose-4-phosphate D-Erythrose-4-phosphate Rubisco shunt,
pentose phosphate pathway (non-oxidative branch),
chorismate biosynthesis,
Calvin-Benson-Bassham cycle 		0.68 0.48 -0.45 C0087
65 C0261 UDP-glucose - UDP-D-glucose quercetin glucoside biosynthesis (Arabidopsis),
abscisic acid glucose ester biosynthesis,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
UDP-glucose biosynthesis (from sucrose),
2,4,6-trinitrotoluene degradation,
galactose degradation I (Leloir pathway),
cytokinins-O-glucoside biosynthesis,
trehalose biosynthesis I,
dolichyl-diphosphooligosaccharide biosynthesis,
phenolic malonylglucosides biosynthesis,
callose biosynthesis,
superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside),
glucosinolate biosynthesis from hexahomomethionine,
coniferin metabolism,
glucosinolate biosynthesis from phenylalanine,
xyloglucan biosynthesis,
glucosinolate biosynthesis from pentahomomethionine,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
glucosinolate biosynthesis from dihomomethionine,
cellulose biosynthesis,
sinapate ester biosynthesis,
superpathway of IAA conjugate biosynthesis,
salicylate glucosides biosynthesis IV,
sucrose biosynthesis I,
glucosinolate biosynthesis from trihomomethionine,
tetrahydrofolate biosynthesis II,
sucrose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis,
coumarin biosynthesis (via 2-coumarate),
superpathway of sucrose and starch metabolism I (non-photosynthetic tissue),
monolignol glucosides biosynthesis,
glucosinolate biosynthesis from homomethionine,
kaempferol glucoside biosynthesis (Arabidopsis),
salicylate glucosides biosynthesis III,
cytokinins 7-N-glucoside biosynthesis,
galactose degradation III,
cytokinins 9-N-glucoside biosynthesis,
glucosinolate biosynthesis from tryptophan,
UDP-galactose biosynthesis,
salicylate glucosides biosynthesis II,
stachyose degradation,
superpathway of sucrose and starch metabolism II (photosynthetic tissue),
UDP-glucose biosynthesis (from glucose 6-phosphate),
sphingolipid biosynthesis (plants),
glucosinolate biosynthesis from tetrahomomethionine,
galactose degradation II,
UDP-L-rhamnose biosynthesis 		0.67 0.48 -0.45 C0261
66 C0221 Quercetin-3-(2''-O-α-rhamnosyl)-O-β-glucosyl-7-O-α-rhamnoside Quercetin-3-(2''-O-α-L-rhamnosyl)-O-β-D-glucosyl-7-O-α-L-rhamnoside - quercetin glucoside biosynthesis (Arabidopsis) 0.64 0.47 -0.44
67 C0257 Tryptophan L-Tryptophan L-Tryptophan glucosinolate biosynthesis from tryptophan,
IAA biosynthesis I,
tryptophan biosynthesis,
camalexin biosynthesis,
tRNA charging 		0.64 0.32 -0.32 C0257
68 C0073 Cysteine L-Cysteine L-Cysteine alanine biosynthesis III,
cysteine biosynthesis I,
gamma-glutamyl cycle (plant pathway),
farnesylcysteine salvage pathway,
molybdenum cofactor biosynthesis,
thiamine biosynthesis II,
cyanide detoxification II,
indole glucosinolate breakdown (insect chewing induced),
glutathione degradation,
glutathione biosynthesis,
molybdenum cofactor biosynthesis II (eukaryotes),
cyanide degradation,
homocysteine and cysteine interconversion,
methionine biosynthesis II,
tRNA charging,
gamma-glutamyl cycle,
coenzyme A biosynthesis 		0.63 0.44 -0.45 C0073
69 C0260 Tyrosine L-(-)-Tyrosine L-Tyrosine tyrosine biosynthesis II,
4-hydroxyphenylpyruvate biosynthesis,
tyrosine degradation I,
tyrosine biosynthesis I,
tRNA charging,
hydroxycinnamic acid tyramine amides biosynthesis 		0.62 0.32 -0.33 C0260
70 C0216 Proline L-Proline L-Proline proline degradation II,
arginine degradation VI (arginase 2 pathway),
L-Ndelta-acetylornithine biosynthesis,
tRNA charging,
citrulline biosynthesis,
proline biosynthesis III 		0.6 0.32 -0.32 C0216
71 C0061 Aspartic acid L-Aspartic acid L-Aspartate purine nucleotide metabolism (phosphotransfer and nucleotide modification),
tRNA charging,
indole-3-acetyl-amino acid biosynthesis,
citrulline-nitric oxide cycle,
asparagine degradation I,
cyanide detoxification II,
asparagine biosynthesis I,
asparagine biosynthesis III (tRNA-dependent),
arginine biosynthesis I,
inosine-5'-phosphate biosynthesis II,
uridine-5'-phosphate biosynthesis,
aspartate biosynthesis,
homoserine biosynthesis,
lysine biosynthesis VI,
aspartate degradation II,
urea cycle,
purine nucleotides de novo biosynthesis II,
NAD biosynthesis I (from aspartate),
IAA degradation IV,
arginine biosynthesis II (acetyl cycle) 		0.58 0.34 -0.34 C0061
72 C0062 Betain - - - 0.55 0.32 -0.34