AT2G36850 : GLUCAN SYNTHASE-LIKE 8
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AGICode AT2G36850
Description glucan synthase-like 8
Gene information
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  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT2G36850 glucan synthase-like 8 GLUCAN SYNTHASE-LIKE 8, ATGSL8,
CHORUS, GSL08, glucan
synthase-like 8
1 0.32 -0.34
2 AT4G17140 pleckstrin homology (PH) domain-containing protein 0.84 0.31 -0.3
3 AT3G50590 Transducin/WD40 repeat-like superfamily protein 0.81 0.32 -0.3
4 AT3G07160 glucan synthase-like 10 glucan synthase-like 10, CALS9,
gsl10, glucan synthase-like 10
0.8 0.3 -0.31
5 AT4G11380 Adaptin family protein 0.76 0.29 -0.33
6 AT5G01400 HEAT repeat-containing protein ENHANCED SILENCING PHENOTYPE 4 0.76 0.31 -0.33
7 AT2G07360 SH3 domain-containing protein 0.76 0.33 -0.33
8 AT1G23230 CONTAINS InterPro DOMAIN/s: Mediator complex subunit Med23
(InterPro:IPR021629); Has 187 Blast hits to 184 proteins in
67 species: Archae - 0; Bacteria - 0; Metazoa - 135; Fungi
- 0; Plants - 43; Viruses - 0; Other Eukaryotes - 9
(source: NCBI BLink).
0.76 0.32 -0.32
9 AT5G66490 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN: plasma
membrane; EXPRESSED IN: 17 plant structures; EXPRESSED
DURING: 9 growth stages; BEST Arabidopsis thaliana protein
match is: unknown protein (TAIR:AT3G50900.1); Has 1807
Blast hits to 1807 proteins in 277 species: Archae - 0;
Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385;
Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
-0.75 0.31 -0.32
10 AT5G11040 TRS120 AtTRS120, TRS120 0.75 0.31 -0.29
11 AT1G02080 transcription regulators 0.75 0.31 -0.3
12 AT3G15980 Coatomer, beta' subunit 0.74 0.3 -0.34
13 AT1G01040 dicer-like 1 ABNORMAL SUSPENSOR 1, DICER-LIKE
1, CARPEL FACTORY, dicer-like 1,
EMBRYO DEFECTIVE 60, EMBRYO
DEFECTIVE 76, SHORT INTEGUMENTS 1,
SUSPENSOR 1
0.74 0.31 -0.32
14 AT5G11700 LOCATED IN: vacuole; EXPRESSED IN: 24 plant structures;
EXPRESSED DURING: 13 growth stages; BEST Arabidopsis
thaliana protein match is: glycine-rich protein
(TAIR:AT4G32920.3); Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).
0.73 0.33 -0.31
15 AT5G20030 Plant Tudor-like RNA-binding protein -0.73 0.32 -0.31
16 AT4G11160 Translation initiation factor 2, small GTP-binding protein 0.73 0.31 -0.3
17 AT1G20960 U5 small nuclear ribonucleoprotein helicase, putative embryo defective 1507 0.73 0.3 -0.31
18 AT4G38600 HEAT repeat ;HECT-domain (ubiquitin-transferase) KAKTUS, UBIQUITIN-PROTEIN LIGASE 3 0.73 0.32 -0.31
19 AT5G15400 U-box domain-containing protein 0.73 0.3 -0.32
20 AT3G50370 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 26 plant
structures; EXPRESSED DURING: 15 growth stages; Has 27734
Blast hits to 16708 proteins in 1259 species: Archae - 81;
Bacteria - 3434; Metazoa - 10876; Fungi - 2514; Plants -
987; Viruses - 212; Other Eukaryotes - 9630 (source: NCBI
BLink).
0.72 0.32 -0.31
21 AT2G47410 WD40/YVTN repeat-like-containing domain;Bromodomain 0.72 0.29 -0.34
22 AT4G38200 SEC7-like guanine nucleotide exchange family protein 0.72 0.32 -0.31
23 AT2G39340 SAC3/GANP/Nin1/mts3/eIF-3 p25 family AtSAC3A, yeast Sac3 homolog A 0.72 0.3 -0.33
24 AT1G50030 target of rapamycin target of rapamycin 0.72 0.3 -0.32
25 AT1G80930 MIF4G domain-containing protein / MA3 domain-containing
protein
0.72 0.33 -0.3
26 AT5G13390 no exine formation 1 NO EXINE FORMATION 1 0.71 0.31 -0.31
27 AT5G26240 chloride channel D ATCLC-D, chloride channel D 0.71 0.31 -0.34
28 AT2G28290 P-loop containing nucleoside triphosphate hydrolases
superfamily protein
CHROMATIN REMODELING COMPLEX
SUBUNIT R 3, SPLAYED
0.71 0.31 -0.34
29 AT2G28390 SAND family protein 0.71 0.34 -0.32
30 AT5G55040 DNA-binding bromodomain-containing protein 0.71 0.31 -0.32
31 AT4G17140 pleckstrin homology (PH) domain-containing protein 0.7 0.31 -0.32
32 AT3G63070 Tudor/PWWP/MBT domain-containing protein 0.7 0.3 -0.31
33 AT1G31810 Formin Homology 14 Formin Homology 14 0.7 0.33 -0.34
34 AT5G06600 ubiquitin-specific protease 12 AtUBP12, ubiquitin-specific
protease 12
0.7 0.29 -0.31
35 AT4G32640 Sec23/Sec24 protein transport family protein 0.7 0.32 -0.32
36 AT2G45540 WD-40 repeat family protein / beige-related 0.69 0.33 -0.31
37 AT3G12810 SNF2 domain-containing protein / helicase domain-containing
protein
chr13, PHOTOPERIOD-INDEPENDENT
EARLY FLOWERING 1, SRCAP
0.69 0.31 -0.33
38 AT1G32490 RNA helicase family protein EMBRYO DEFECTIVE 2733, ENHANCED
SILENCING PHENOTYPE 3
0.69 0.3 -0.31
39 AT1G10390 Nucleoporin autopeptidase 0.69 0.33 -0.3
40 AT2G47980 sister-chromatid cohesion protein 3 SISTER-CHROMATID COHESION PROTEIN
3, sister-chromatid cohesion
protein 3
0.69 0.29 -0.3
41 AT3G10220 tubulin folding cofactor B EMBRYO DEFECTIVE 2804 -0.69 0.33 -0.32
42 AT5G43130 TBP-associated factor 4 TBP-associated factor 4,
TBP-associated factor 4B
0.69 0.3 -0.3
43 AT2G03140 alpha/beta-Hydrolases superfamily protein 0.68 0.33 -0.29
44 AT3G07100 Sec23/Sec24 protein transport family protein AtSEC24A, ENDOPLASMIC RETICULUM
MORPHOLOGY 2, SEC24A
0.68 0.31 -0.3
45 AT1G01960 SEC7-like guanine nucleotide exchange family protein embryo sac development arrest 10 0.68 0.35 -0.3
46 AT1G58230 binding 0.68 0.3 -0.31
47 AT4G01290 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 24 plant
structures; EXPRESSED DURING: 15 growth stages; Has 1744
Blast hits to 1308 proteins in 219 species: Archae - 0;
Bacteria - 241; Metazoa - 793; Fungi - 253; Plants - 108;
Viruses - 0; Other Eukaryotes - 349 (source: NCBI BLink).
0.68 0.3 -0.31
48 AT2G02560 cullin-associated and neddylation dissociated CULLIN-ASSOCIATED AND NEDDYLATION
DISSOCIATED 1, cullin-associated
and neddylation dissociated, ETA2,
HEMIVENATA, TIP120
0.68 0.34 -0.31
49 AT3G11650 NDR1/HIN1-like 2 NDR1/HIN1-like 2 -0.68 0.32 -0.32
50 AT4G03550 glucan synthase-like 5 glucan synthase-like 5, ATGSL5,
GSL05, glucan synthase-like 5,
GLUCAN SYNTHASE-LIKE 5, POWDERY
MILDEW RESISTANT 4
0.68 0.34 -0.31
51 AT5G16280 Tetratricopeptide repeat (TPR)-like superfamily protein 0.68 0.34 -0.3
52 AT3G54670 Structural maintenance of chromosomes (SMC) family protein ATSMC1, STRUCTURAL MAINTENANCE OF
CHROMOSOMES 1, TITAN8
0.67 0.32 -0.32
53 AT1G48410 Stabilizer of iron transporter SufD / Polynucleotidyl
transferase
ARGONAUTE 1 0.67 0.3 -0.33
54 AT2G38160 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT2G40070.2); Has 972 Blast hits
to 731 proteins in 211 species: Archae - 0; Bacteria - 236;
Metazoa - 194; Fungi - 201; Plants - 218; Viruses - 32;
Other Eukaryotes - 91 (source: NCBI BLink).
-0.67 0.32 -0.28
55 AT5G42220 Ubiquitin-like superfamily protein 0.67 0.32 -0.32
56 AT5G53440 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED
DURING: 15 growth stages; Has 1807 Blast hits to 1807
proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa
- 736; Fungi - 347; Plants - 385; Viruses - 0; Other
Eukaryotes - 339 (source: NCBI BLink).
0.67 0.33 -0.3
57 AT1G60010 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: N-terminal protein myristoylation; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 22 plant
structures; EXPRESSED DURING: 13 growth stages; BEST
Arabidopsis thaliana protein match is: unknown protein
(TAIR:AT1G10530.1); Has 185 Blast hits to 185 proteins in
18 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi -
3; Plants - 180; Viruses - 0; Other Eukaryotes - 2 (source:
NCBI BLink).
-0.66 0.3 -0.32
58 AT5G18230 transcription regulator NOT2/NOT3/NOT5 family protein 0.66 0.32 -0.31
59 AT1G26110 decapping 5 decapping 5 0.66 0.32 -0.3
60 AT2G16485 nucleic acid binding;zinc ion binding;DNA binding 0.66 0.31 -0.31
61 AT1G67140 HEAT repeat-containing protein SWEETIE 0.66 0.32 -0.31
62 AT4G00630 K+ efflux antiporter 2 ATKEA2, K+ efflux antiporter 2 0.66 0.31 -0.32
63 AT3G07410 RAB GTPase homolog A5B RAB GTPase homolog A5B, RAB GTPase
homolog A5B
-0.66 0.32 -0.3
64 AT1G79600 Protein kinase superfamily protein 0.66 0.28 -0.32
65 AT3G21430 DNA binding ALWAYS EARLY 3, ARABIDOPSIS
THALIANA ALWAYS EARLY 3
0.66 0.32 -0.29
66 AT3G59770 sacI homology domain-containing protein / WW
domain-containing protein
ARABIDOPSIS THALIANA SUPPRESSOR OF
ACTIN 9, SUPPRESSOR OF ACTIN 9
0.66 0.32 -0.3
67 AT1G17350 NADH:ubiquinone oxidoreductase intermediate-associated
protein 30
-0.66 0.31 -0.32
68 AT1G80070 Pre-mRNA-processing-splicing factor EMBRYO DEFECTIVE 14, EMBRYO
DEFECTIVE 177, EMBRYO DEFECTIVE
33, ABNORMAL SUSPENSOR 2
0.66 0.29 -0.33
69 AT3G51120 DNA binding;zinc ion binding;nucleic acid binding;nucleic
acid binding
0.65 0.32 -0.32
70 AT5G15700 DNA/RNA polymerases superfamily protein 0.65 0.31 -0.32
71 AT5G43830 Aluminium induced protein with YGL and LRDR motifs -0.65 0.3 -0.32
72 AT3G11960 Cleavage and polyadenylation specificity factor (CPSF) A
subunit protein
0.65 0.32 -0.31
73 AT4G29790 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT2G19390.1); Has 538 Blast hits
to 357 proteins in 124 species: Archae - 0; Bacteria - 74;
Metazoa - 109; Fungi - 58; Plants - 105; Viruses - 2; Other
Eukaryotes - 190 (source: NCBI BLink).
0.65 0.31 -0.34
74 AT1G30490 Homeobox-leucine zipper family protein / lipid-binding
START domain-containing protein
ATHB9, PHAVOLUTA 0.65 0.3 -0.32
75 AT1G08600 P-loop containing nucleoside triphosphate hydrolases
superfamily protein
ATRX, CHR20 0.65 0.31 -0.31
76 AT3G43300 HOPM interactor 7 HOPM interactor 7, BFA-VISUALIZED
ENDOCYTIC TRAFFICKING DEFECTIVE1
0.65 0.32 -0.33
77 AT1G24706 THO2 AtTHO2, EMBRYO DEFECTIVE 2793,
THO2
0.65 0.31 -0.33
78 AT2G35630 ARM repeat superfamily protein GEM1, MICROTUBULE ORGANIZATION 1 0.65 0.31 -0.31
79 AT1G74250 DNAJ heat shock N-terminal domain-containing protein 0.65 0.31 -0.31
80 AT4G17330 G2484-1 protein G2484-1 protein, G2484-1 protein 0.65 0.33 -0.3
81 AT4G03390 STRUBBELIG-receptor family 3 STRUBBELIG-receptor family 3 0.65 0.32 -0.3
82 AT5G38560 Protein kinase superfamily protein proline-rich extensin-like
receptor kinase 8, proline-rich
extensin-like receptor kinase 8
0.65 0.33 -0.31
83 AT5G55780 Cysteine/Histidine-rich C1 domain family protein -0.64 0.32 -0.33
84 AT1G10320 Zinc finger C-x8-C-x5-C-x3-H type family protein 0.64 0.3 -0.3
85 AT2G04830 Protein of unknown function (DUF295) 0.64 0.3 -0.32
86 AT3G12680 floral homeotic protein (HUA1) ENHANCER OF AG-4 1 0.64 0.31 -0.33
87 AT4G35800 RNA polymerase II large subunit RNA polymerase II large subunit,
RNA POLYMERASE II LARGE SUBUNIT,
RNA_POL_II_LSRNA_POL_II_LS, RNA
POLYMERASE II LARGE SUBUNIT
0.64 0.31 -0.31
88 AT1G77300 histone methyltransferases(H3-K4 specific);histone
methyltransferases(H3-K36 specific)
ASH1 HOMOLOG 2, CAROTENOID
CHLOROPLAST REGULATORY1, EARLY
FLOWERING IN SHORT DAYS, LAZARUS
2, SET DOMAIN GROUP 8
0.64 0.31 -0.33
89 AT5G24350 CONTAINS InterPro DOMAIN/s: Secretory pathway Sec39
(InterPro:IPR013244); Has 1807 Blast hits to 1807 proteins
in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736;
Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes -
339 (source: NCBI BLink).
0.63 0.33 -0.31
90 AT4G39420 unknown protein; Has 46 Blast hits to 40 proteins in 10
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 44; Viruses - 0; Other Eukaryotes - 2 (source:
NCBI BLink).
0.63 0.3 -0.31
91 AT2G39480 P-glycoprotein 6 ATP-binding cassette B6,
P-glycoprotein 6
0.63 0.3 -0.31
92 AT2G17930 Phosphatidylinositol 3- and 4-kinase family protein with
FAT domain
0.63 0.31 -0.32
93 AT1G71820 SEC6 SEC6 0.63 0.31 -0.32
94 AT3G15630 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED
DURING: 15 growth stages; BEST Arabidopsis thaliana protein
match is: unknown protein (TAIR:AT1G52720.1); Has 61 Blast
hits to 61 proteins in 13 species: Archae - 0; Bacteria -
0; Metazoa - 0; Fungi - 0; Plants - 61; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).
-0.63 0.31 -0.3
95 AT5G07280 Leucine-rich repeat transmembrane protein kinase EXCESS MICROSPOROCYTES1, EXTRA
SPOROGENOUS CELLS
0.63 0.32 -0.33
96 AT5G25210 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT4G32030.1); Has 30201 Blast
hits to 17322 proteins in 780 species: Archae - 12;
Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants -
5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI
BLink).
-0.63 0.3 -0.3
97 AT5G59150 RAB GTPase homolog A2D ARABIDOPSIS RAB GTPASE HOMOLOG
A2D, RAB GTPase homolog A2D, RAB
GTPase homolog A2D
-0.62 0.31 -0.31
98 AT5G13090 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT1G24270.1); Has 30201 Blast
hits to 17322 proteins in 780 species: Archae - 12;
Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants -
5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI
BLink).
-0.62 0.31 -0.31
99 AT5G56870 beta-galactosidase 4 beta-galactosidase 4 -0.62 0.29 -0.31
100 AT2G17450 RING-H2 finger A3A RING-H2 finger A3A -0.62 0.31 -0.33
101 AT5G63480 unknown protein; Has 30201 Blast hits to 17322 proteins in
780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338;
Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes
- 2996 (source: NCBI BLink).
-0.62 0.33 -0.33
102 AT4G25410 basic helix-loop-helix (bHLH) DNA-binding superfamily
protein
-0.61 0.32 -0.33
103 AT1G61840 Cysteine/Histidine-rich C1 domain family protein -0.61 0.3 -0.31
104 AT5G51400 PLAC8 family protein -0.61 0.3 -0.32
105 AT5G47830 unknown protein; Has 35333 Blast hits to 34131 proteins in
2444 species: Archae - 798; Bacteria - 22429; Metazoa -
974; Fungi - 991; Plants - 531; Viruses - 0; Other
Eukaryotes - 9610 (source: NCBI BLink).
-0.61 0.32 -0.35
106 AT1G47210 cyclin-dependent protein kinase 3;2 cyclin-dependent protein kinase
3;2
-0.61 0.31 -0.29
107 AT5G60230 splicing endonuclease 2 SPLICING ENDONUCLEASE 2, splicing
endonuclease 2
-0.61 0.32 -0.31
108 AT2G46000 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
biological_process unknown; LOCATED IN: endomembrane
system; EXPRESSED IN: 24 plant structures; EXPRESSED
DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s:
Mesoderm development candidate 2 (InterPro:IPR019330); Has
31 Blast hits to 31 proteins in 13 species: Archae - 0;
Bacteria - 0; Metazoa - 5; Fungi - 0; Plants - 26; Viruses
- 0; Other Eukaryotes - 0 (source: NCBI BLink).
-0.6 0.31 -0.31
109 AT4G23730 Galactose mutarotase-like superfamily protein -0.6 0.32 -0.3
110 AT2G28355 low-molecular-weight cysteine-rich 5 low-molecular-weight cysteine-rich
5
-0.59 0.32 -0.33
111 AT2G07505 zinc ion binding -0.59 0.31 -0.32
112 AT1G49170 Protein of unknown function (DUF167) -0.58 0.33 -0.31
113 AT2G01090 Ubiquinol-cytochrome C reductase hinge protein -0.58 0.3 -0.3
114 AT1G15220 cytochrome c biogenesis protein family ATCCMH, CCMH -0.57 0.29 -0.32
115 AT1G16530 ASYMMETRIC LEAVES 2-like 9 ASYMMETRIC LEAVES 2-like 9, LOB
DOMAIN-CONTAINING PROTEIN 3
-0.57 0.32 -0.34
116 AT5G17350 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: N-terminal protein myristoylation; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 15 plant
structures; EXPRESSED DURING: 8 growth stages; BEST
Arabidopsis thaliana protein match is: unknown protein
(TAIR:AT3G03280.1); Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).
-0.56 0.29 -0.33
117 AT2G41250 Haloacid dehalogenase-like hydrolase (HAD) superfamily
protein
-0.56 0.32 -0.31
118 AT4G39756 Galactose oxidase/kelch repeat superfamily protein -0.56 0.3 -0.29
119 AT5G16650 Chaperone DnaJ-domain superfamily protein -0.55 0.31 -0.34
120 AT3G06080 Plant protein of unknown function (DUF828) TRICHOME BIREFRINGENCE-LIKE 10 -0.55 0.32 -0.34
121 AT1G33990 methyl esterase 14 METHYL ESTERASE 14, methyl
esterase 14
-0.55 0.31 -0.33
122 AT1G12610 Integrase-type DNA-binding superfamily protein DWARF AND DELAYED FLOWERING 1 -0.55 0.31 -0.31
123 AT4G14630 germin-like protein 9 germin-like protein 9 -0.55 0.32 -0.31
124 AT5G60630 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
biological_process unknown; LOCATED IN: endomembrane
system; EXPRESSED IN: 17 plant structures; EXPRESSED
DURING: 6 growth stages; BEST Arabidopsis thaliana protein
match is: hydroxyproline-rich glycoprotein family protein
(TAIR:AT3G45230.1); Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).
-0.54 0.29 -0.31
125 AT2G12610 transposable element gene -0.54 0.32 -0.34
126 AT3G50060 myb domain protein 77 myb domain protein 77 -0.54 0.3 -0.3
Metabolite information
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  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
127 C0074 Cystine L-Cystine L-Cystine protein precursor 0.82 0.45 -0.45 C0074
128 C0110 Guanosine - Guanosine guanosine nucleotides degradation I,
guanine and guanosine salvage II,
guanosine nucleotides degradation II,
guanine and guanosine salvage III
0.77 0.47 -0.46 C0110
129 C0144 Maltose D-Maltose α-Maltose starch degradation II 0.71 0.44 -0.47 C0144
130 C0173 MST_2301.7 - - - 0.7 0.44 -0.43
131 C0117 Hydroxyproline (2S,4R)-Hydroxyproline 4-Hydroxy-L-proline protein precursor 0.63 0.43 -0.45 C0117