AGICode | AT5G22720 |
Description | F-box/RNI-like superfamily protein |
Gene Code | Description / Information | Gene name | Correlation | link | ||||
---|---|---|---|---|---|---|---|---|
pcc | 2.5% | 97.5% | PPI | |||||
1 | AT5G22720 | F-box/RNI-like superfamily protein | 1 | 0.31 | -0.32 | |||
2 | AT1G54240 | winged-helix DNA-binding transcription factor family protein |
-0.76 | 0.29 | -0.32 | |||
3 | AT3G45420 | Concanavalin A-like lectin protein kinase family protein | 0.74 | 0.32 | -0.33 | |||
4 | AT3G56300 | Cysteinyl-tRNA synthetase, class Ia family protein | 0.74 | 0.32 | -0.33 | |||
5 | AT5G08430 | SWIB/MDM2 domain;Plus-3;GYF | 0.73 | 0.32 | -0.31 | |||
6 | AT5G35170 | adenylate kinase family protein | 0.71 | 0.33 | -0.32 | |||
7 | AT4G04970 | glucan synthase-like 1 | GLUCAN SYNTHASE LIKE 1, GLUCAN SYNTHASE LIKE-1, GSL01, glucan synthase-like 1 |
0.71 | 0.33 | -0.3 | ||
8 | AT4G03205 | Coproporphyrinogen III oxidase | hemf2 | 0.69 | 0.3 | -0.32 | ||
9 | AT2G27900 | CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF2451, C-terminal (InterPro:IPR019514), Vacuolar protein sorting-associated protein 54 (InterPro:IPR019515); Has 316 Blast hits to 252 proteins in 92 species: Archae - 0; Bacteria - 2; Metazoa - 200; Fungi - 2; Plants - 68; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink). |
0.69 | 0.33 | -0.32 | |||
10 | AT5G38140 | nuclear factor Y, subunit C12 | nuclear factor Y, subunit C12 | 0.68 | 0.34 | -0.31 | ||
11 | AT2G36720 | Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger domain |
0.67 | 0.31 | -0.32 | |||
12 | AT1G74160 | unknown protein; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G18620.1); Has 3407 Blast hits to 2217 proteins in 314 species: Archae - 0; Bacteria - 264; Metazoa - 1296; Fungi - 318; Plants - 346; Viruses - 34; Other Eukaryotes - 1149 (source: NCBI BLink). |
0.67 | 0.34 | -0.31 | |||
13 | AT4G14530 | BEST Arabidopsis thaliana protein match is: AGAMOUS-like 97 (TAIR:AT1G46408.1); Has 21 Blast hits to 21 proteins in 2 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 21; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink). |
0.64 | 0.32 | -0.31 | |||
14 | AT3G46580 | methyl-CPG-binding domain protein 5 | ATMBD5, METHYL-CPG-BINDING DOMAIN PROTEIN 05, methyl-CPG-binding domain protein 5 |
0.64 | 0.3 | -0.3 | ||
15 | AT2G35910 | RING/U-box superfamily protein | -0.64 | 0.33 | -0.32 | |||
16 | AT5G46400 | Tetratricopeptide repeat (TPR)-like superfamily protein | AT PRP39-2, PRP39-2 | 0.63 | 0.33 | -0.3 | ||
17 | AT1G03910 | EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cactin protein, cactus-binding domain, C-terminal (InterPro:IPR019134), Cactin, central region (InterPro:IPR018816); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G36815.2); Has 11711 Blast hits to 7382 proteins in 452 species: Archae - 31; Bacteria - 352; Metazoa - 6006; Fungi - 1138; Plants - 599; Viruses - 33; Other Eukaryotes - 3552 (source: NCBI BLink). |
0.63 | 0.31 | -0.32 | |||
18 | AT1G79820 | Major facilitator superfamily protein | SUPPRESSOR OF G PROTEIN BETA1 | 0.63 | 0.33 | -0.31 | ||
19 | AT5G55300 | DNA topoisomerase I alpha | MGOUN 1, TOPOISOMERASE 1, DNA topoisomerase I alpha |
0.63 | 0.31 | -0.3 | ||
20 | AT4G27180 | kinesin 2 | kinesin 2, KINESIN-LIKE PROTEIN IN ARABIDOPSIS THALIANA B |
0.62 | 0.29 | -0.31 | ||
21 | AT3G17980 | Calcium-dependent lipid-binding (CaLB domain) family protein |
Arabidopsis thaliana C2 domain, C2 domain |
0.62 | 0.34 | -0.33 | ||
22 | AT3G28200 | Peroxidase superfamily protein | -0.62 | 0.34 | -0.33 | |||
23 | AT1G48870 | Transducin/WD40 repeat-like superfamily protein | 0.62 | 0.3 | -0.33 | |||
24 | AT3G26350 | LOCATED IN: chloroplast; EXPRESSED IN: root, pedicel, carpel, stamen; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Late embryogenesis abundant protein, group 2 (InterPro:IPR004864); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G13050.1); Has 3534 Blast hits to 2704 proteins in 342 species: Archae - 6; Bacteria - 192; Metazoa - 1076; Fungi - 505; Plants - 1162; Viruses - 224; Other Eukaryotes - 369 (source: NCBI BLink). |
0.62 | 0.31 | -0.32 | |||
25 | AT2G36040 | transposable element gene | 0.61 | 0.32 | -0.33 | |||
26 | AT5G60070 | ankyrin repeat family protein | 0.61 | 0.33 | -0.32 | |||
27 | AT3G02940 | myb domain protein 107 | myb domain protein 107, myb domain protein 107 |
-0.61 | 0.31 | -0.33 | ||
28 | AT3G26560 | ATP-dependent RNA helicase, putative | 0.6 | 0.3 | -0.32 | |||
29 | AT3G20860 | NIMA-related kinase 5 | NIMA-related kinase 5, NIMA-related kinase 5 |
0.6 | 0.32 | -0.32 | ||
30 | AT3G58080 | unknown protein; Has 3 Blast hits to 3 proteins in 2 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 3; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink). |
-0.6 | 0.29 | -0.3 | |||
31 | AT2G21490 | dehydrin LEA | dehydrin LEA | 0.6 | 0.32 | -0.31 | ||
32 | AT2G42560 | late embryogenesis abundant domain-containing protein / LEA domain-containing protein |
0.6 | 0.34 | -0.32 | |||
33 | AT5G25490 | Ran BP2/NZF zinc finger-like superfamily protein | 0.6 | 0.31 | -0.33 | |||
34 | AT1G61500 | S-locus lectin protein kinase family protein | 0.59 | 0.3 | -0.33 | |||
35 | AT1G28160 | Integrase-type DNA-binding superfamily protein | -0.59 | 0.32 | -0.31 | |||
36 | AT2G20460 | transposable element gene | 0.59 | 0.31 | -0.32 | |||
37 | AT5G56160 | Sec14p-like phosphatidylinositol transfer family protein | 0.59 | 0.32 | -0.3 | |||
38 | AT4G05370 | BCS1 AAA-type ATPase | -0.59 | 0.34 | -0.32 | |||
39 | AT3G47660 | Regulator of chromosome condensation (RCC1) family protein | -0.59 | 0.32 | -0.3 | |||
40 | AT3G54060 | unknown protein; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G37960.2); Has 455 Blast hits to 322 proteins in 98 species: Archae - 0; Bacteria - 178; Metazoa - 88; Fungi - 75; Plants - 28; Viruses - 2; Other Eukaryotes - 84 (source: NCBI BLink). |
0.59 | 0.31 | -0.31 | |||
41 | AT2G23860 | pseudogene, similar to VAP27, blastp match of 56% identity and 1.3e-25 P-value to GP|6688926|emb|CAB65313.1||AJ251365 VAP27 {Nicotiana plumbaginifolia} |
0.59 | 0.3 | -0.3 | |||
42 | AT1G17890 | NAD(P)-binding Rossmann-fold superfamily protein | GER2 | -0.59 | 0.31 | -0.3 | ||
43 | AT3G20990 | transposable element gene | -0.58 | 0.3 | -0.31 | |||
44 | AT1G27960 | evolutionarily conserved C-terminal region 9 | evolutionarily conserved C-terminal region 9 |
0.58 | 0.28 | -0.32 | ||
45 | AT3G32060 | transposable element gene | -0.58 | 0.32 | -0.32 | |||
46 | AT5G49555 | FAD/NAD(P)-binding oxidoreductase family protein | 0.58 | 0.3 | -0.31 | |||
47 | AT1G74620 | RING/U-box superfamily protein | 0.57 | 0.31 | -0.31 | |||
48 | AT3G14090 | exocyst subunit exo70 family protein D3 | exocyst subunit exo70 family protein D3, exocyst subunit exo70 family protein D3 |
-0.57 | 0.32 | -0.3 | ||
49 | AT1G22860 | Vacuolar sorting protein 39 | 0.57 | 0.32 | -0.3 | |||
50 | AT2G14380 | transposable element gene | -0.57 | 0.3 | -0.32 | |||
51 | AT5G35430 | Tetratricopeptide repeat (TPR)-like superfamily protein | -0.57 | 0.32 | -0.33 | |||
52 | AT2G31110 | Plant protein of unknown function (DUF828) | TRICHOME BIREFRINGENCE-LIKE 40 | -0.57 | 0.32 | -0.29 | ||
53 | AT1G23830 | unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 9 growth stages; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G23840.1); Has 57 Blast hits to 52 proteins in 7 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 57; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink). |
-0.57 | 0.32 | -0.33 | |||
54 | AT4G18400 | unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). |
0.56 | 0.3 | -0.3 | |||
55 | AT1G21430 | Flavin-binding monooxygenase family protein | YUC11 | 0.56 | 0.3 | -0.32 | ||
56 | AT2G18640 | geranylgeranyl pyrophosphate synthase 4 | geranylgeranyl pyrophosphate synthase 4 |
-0.56 | 0.32 | -0.34 | ||
57 | AT3G29220 | transposable element gene | 0.56 | 0.33 | -0.32 | |||
58 | AT1G49400 | Nucleic acid-binding, OB-fold-like protein | embryo defective 1129 | -0.56 | 0.31 | -0.31 | ||
59 | AT1G54170 | CTC-interacting domain 3 | CTC-interacting domain 3 | 0.56 | 0.31 | -0.29 | ||
60 | AT2G44990 | carotenoid cleavage dioxygenase 7 | ATCCD7, carotenoid cleavage dioxygenase 7, MAX3 |
0.56 | 0.31 | -0.33 | ||
61 | AT2G40790 | C-terminal cysteine residue is changed to a serine 2 | C-terminal cysteine residue is changed to a serine 2, C-terminal cysteine residue is changed to a serine 2 |
-0.55 | 0.3 | -0.32 | ||
62 | AT3G22700 | F-box and associated interaction domains-containing protein | -0.55 | 0.31 | -0.32 | |||
63 | AT3G62190 | Chaperone DnaJ-domain superfamily protein | 0.55 | 0.32 | -0.31 | |||
64 | AT3G28030 | 5'-3' exonuclease family protein | ULTRAVIOLET HYPERSENSITIVE 3, UV REPAIR DEFECTIVE 1 |
0.55 | 0.32 | -0.31 | ||
65 | AT4G33390 | Plant protein of unknown function (DUF827) | -0.55 | 0.33 | -0.31 | |||
66 | AT5G62960 | unknown protein; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G10660.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). |
0.55 | 0.34 | -0.33 | |||
67 | AT3G42730 | transposable element gene | -0.55 | 0.32 | -0.3 | |||
68 | AT2G22310 | ubiquitin-specific protease 4 | ubiquitin-specific protease 4, ubiquitin-specific protease 4 |
0.55 | 0.32 | -0.32 | ||
69 | AT3G06290 | SAC3/GANP/Nin1/mts3/eIF-3 p25 family | AtSAC3B, yeast Sac3 homolog B | 0.55 | 0.33 | -0.32 | ||
70 | AT5G44820 | Nucleotide-diphospho-sugar transferase family protein | -0.54 | 0.33 | -0.31 | |||
71 | AT5G67430 | Acyl-CoA N-acyltransferases (NAT) superfamily protein | -0.54 | 0.34 | -0.32 | |||
72 | AT5G25910 | receptor like protein 52 | receptor like protein 52, receptor like protein 52 |
-0.54 | 0.33 | -0.31 | ||
73 | AT5G16320 | FRIGIDA like 1 | FRIGIDA like 1 | -0.53 | 0.3 | -0.32 | ||
74 | AT2G13020 | transposable element gene | -0.53 | 0.32 | -0.31 | |||
75 | AT3G03020 | unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; Has 5 Blast hits to 5 proteins in 1 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink). |
-0.53 | 0.31 | -0.33 | |||
76 | AT2G23680 | Cold acclimation protein WCOR413 family | -0.52 | 0.32 | -0.31 | |||
77 | AT3G27980 | Plant invertase/pectin methylesterase inhibitor superfamily | -0.52 | 0.33 | -0.31 | |||
78 | AT5G38400 | unknown protein; Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). |
-0.51 | 0.33 | -0.32 | |||
79 | AT1G06770 | DREB2A-interacting protein 1 | DREB2A-interacting protein 1 | -0.51 | 0.31 | -0.31 |
CID | Metabolite name | Pathway Information | Correlation | link | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Compound name | Stereochemistry | Aracyc name | pcc | 2.5% | 97.5% | PPI | ||||
80 | C0234 | Sinapoyl glucose | 1-O-Sinapoyl-β-D-glucose | 1-O-Sinapoyl-β-D-glucose | sinapate ester biosynthesis | 0.8 | 0.45 | -0.44 | ||
81 | C0099 | Glucose-1-phosphate | α,β-D-Glucose-1-phosphate | α-D-Glucose-1-phosphate; β-D-Glucose-1-phosphate | galactose degradation I (Leloir pathway) | 0.73 | 0.45 | -0.46 | ||
82 | C0186 | NAD | - | NAD+ | ammonia assimilation cycle II, aspartate degradation II, adenosine nucleotides degradation I, plant sterol biosynthesis II, UDP-D-xylose and UDP-D-glucuronate biosynthesis, NAD biosynthesis I (from aspartate), ethanol degradation IV (peroxisomal), abscisic acid biosynthesis, palmitate biosynthesis II (bacteria and plants), zeaxanthin biosynthesis, sucrose degradation to ethanol and lactate (anaerobic), glutamate degradation IV, stearate biosynthesis II (plants), guanosine nucleotides degradation II, glutamate degradation I, mannitol degradation II, glycerol-3-phosphate shuttle, 2-ketoglutarate dehydrogenase complex, arginine degradation I (arginase pathway), aerobic respiration (alternative oxidase pathway), branched-chain alpha-keto acid dehydrogenase complex, 4-aminobutyrate degradation IV, glycolysis I, glycine cleavage complex, lysine degradation II, fatty acid beta-oxidation II (core pathway), nitrate reduction II (assimilatory), TCA cycle variation V (plant), leucine degradation I, thiamine biosynthesis II, acetaldehyde biosynthesis I, sorbitol degradation I, glutamine biosynthesis III, aerobic respiration (cytochrome c), ethanol degradation I, ascorbate biosynthesis I (L-galactose pathway), glycolysis IV (plant cytosol), benzoate biosynthesis II (CoA-independent, non-beta-oxidative), siroheme biosynthesis, TCA cycle variation III (eukaryotic), isoleucine degradation I, pyridine nucleotide cycling (plants), tyrosine biosynthesis I, gluconeogenesis I, glycine betaine biosynthesis III (plants), traumatin and (Z)-3-hexen-1-yl acetate biosynthesis, NAD/NADH phosphorylation and dephosphorylation, guanosine nucleotides degradation I, purine nucleotides de novo biosynthesis II, acetyl-CoA biosynthesis (from pyruvate), serine biosynthesis, photorespiration, histidine biosynthesis, glyoxylate cycle, jasmonic acid biosynthesis, alanine degradation II (to D-lactate), a ubiquinone + NADH + H+ -> a ubiquinol + NAD+, putrescine degradation IV, brassinosteroid biosynthesis III, fatty acid elongation -- saturated, pyruvate fermentation to ethanol II, beta-alanine biosynthesis II, 4-hydroxybenzoate biosynthesis V, plant sterol biosynthesis, urate biosynthesis/inosine 5'-phosphate degradation, phenylalanine degradation III, glutamate biosynthesis IV, leucine biosynthesis, fatty acid alpha-oxidation, a ubiquinone + NADH + H+ -> NAD+ + a ubiquinol, Fe(III)-reduction and Fe(II) transport, purine nucleotide metabolism (phosphotransfer and nucleotide modification), phenylethanol biosynthesis, pyruvate fermentation to lactate, superpathway of glyoxylate cycle and fatty acid degradation, fatty acid omega-oxidation, galactose degradation III, ethanol degradation II (cytosol), sucrose biosynthesis I, valine degradation I, folate transformations II |
0.72 | 0.45 | -0.45 | ||
83 | C0005 | β-Fructose-6-phosphate | β-D-Fructose-6-phosphate | D-Fructose-6-phosphate | starch biosynthesis, Rubisco shunt, Calvin-Benson-Bassham cycle, mannitol degradation II, ascorbate biosynthesis I (L-galactose pathway), UDP-N-acetyl-D-glucosamine biosynthesis II, GDP-mannose biosynthesis, mannose degradation, sucrose biosynthesis I, sucrose degradation III, glycolysis IV (plant cytosol), pentose phosphate pathway (non-oxidative branch), glycolysis I, superpathway of sucrose and starch metabolism II (photosynthetic tissue), D-mannose degradation, gluconeogenesis I |
0.71 | 0.32 | -0.31 | ||
84 | C0149 | Mevalonolactone | D,L-Mevalonolactone | - | terpenoid biosynthesis | 0.7 | 0.41 | -0.43 | ||
85 | C0032 | 3-Phosphoglyceric acid | 3-Phospho-(R)-glyceric acid | 3-Phosphoglycerate | glycolysis I, gluconeogenesis I, Calvin-Benson-Bassham cycle, sucrose biosynthesis I, serine biosynthesis, photorespiration, Rubisco shunt, glycolysis IV (plant cytosol) |
0.67 | 0.43 | -0.45 | ||
86 | C0053 | ADP | - | ADP | phosphatidylcholine biosynthesis I, mannitol degradation II, lipid IVA biosynthesis, stachyose degradation, Rubisco shunt, copper transport II, glycerol degradation IV, chorismate biosynthesis, folate polyglutamylation II, galactose degradation III, D-myo-inositol (1,4,5)-trisphosphate biosynthesis, UDP-L-arabinose biosynthesis II (from L-arabinose), cadmium transport I, folate polyglutamylation, coenzyme A biosynthesis, sulfate activation for sulfonation, 1,4-dihydroxy-2-naphthoate biosynthesis II (plants), pyrimidine deoxyribonucleotides de novo biosynthesis I, galactose degradation II, inosine-5'-phosphate biosynthesis II, ribose degradation, acetyl-CoA biosynthesis (from citrate), inositol pyrophosphates biosynthesis, fatty acid biosynthesis initiation I, xylose degradation I, adenine and adenosine salvage VI, TCA cycle variation III (eukaryotic), tetrahydrofolate biosynthesis II, phosphatidylethanolamine biosynthesis II, pyridoxal 5'-phosphate salvage pathway, citrulline biosynthesis, trans-zeatin biosynthesis, glutamine biosynthesis I, arginine biosynthesis II (acetyl cycle), L-Ndelta-acetylornithine biosynthesis, mevalonate pathway I, methionine biosynthesis II, trehalose degradation II (trehalase), citrulline degradation, methionine salvage pathway, TCA cycle variation V (plant), chlorophyllide a biosynthesis I, starch degradation I, methylerythritol phosphate pathway, pyridine nucleotide cycling (plants), ceramide degradation, biotin-carboxyl carrier protein assembly, purine nucleotide metabolism (phosphotransfer and nucleotide modification), UDP-D-galacturonate biosynthesis II (from D-galacturonate), asparagine biosynthesis III (tRNA-dependent), superpathway of glyoxylate cycle and fatty acid degradation, NAD/NADH phosphorylation and dephosphorylation, 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3), galactose degradation I (Leloir pathway), uridine-5'-phosphate biosynthesis, lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3), sucrose degradation III, lysine biosynthesis VI, sphingolipid biosynthesis (plants), choline biosynthesis I, GDP-glucose biosynthesis, photorespiration, gamma-glutamyl cycle (plant pathway), 5-aminoimidazole ribonucleotide biosynthesis I, gamma-glutamyl cycle, thiamine biosynthesis II, proline biosynthesis III, glutathione biosynthesis, folate transformations II, ornithine biosynthesis, diphthamide biosynthesis, S-methyl-5'-thioadenosine degradation I, starch biosynthesis, arginine biosynthesis I, homoserine biosynthesis, flavin biosynthesis I (bacteria and plants), sucrose biosynthesis I, leucine degradation I, glycolysis I, pyrimidine ribonucleotides interconversion, 1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza), glycolysis IV (plant cytosol), Calvin-Benson-Bassham cycle, UDP-D-glucuronate biosynthesis (from myo-inositol), guanine and guanosine salvage III, glutamine biosynthesis III, L-glutamine biosynthesis II (tRNA-dependent), GDP-L-fucose biosynthesis II (from L-fucose), nitrate reduction II (assimilatory), ammonia assimilation cycle II, gluconeogenesis I, threonine biosynthesis from homoserine, mannose degradation, urea cycle, lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3), biotin biosynthesis II |
0.64 | 0.46 | -0.45 | ||
87 | C0195 | Phenylpyruvic acid | - | Phenylpyruvate | phenylalanine degradation III | 0.58 | 0.45 | -0.45 |