C0216 : Proline
Query Information
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ID C0216
Compound name Proline
External link   http://pmn.plantcyc.org/ARA/NEW-IMAGE?type=COMPOUND&object=PRO
Pathway Information proline degradation II,
arginine degradation VI (arginase 2 pathway),
L-Ndelta-acetylornithine biosynthesis,
tRNA charging,
citrulline biosynthesis,
proline biosynthesis III
Gene information
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  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT3G13580 Ribosomal protein L30/L7 family protein -0.74 0.34 -0.31
2 AT3G15790 methyl-CPG-binding domain 11 ATMBD11, methyl-CPG-binding domain
11		 0.72 0.31 -0.32
3 AT5G23900 Ribosomal protein L13e family protein -0.69 0.32 -0.3
4 AT5G23140 nuclear-encoded CLP protease P7 CLPP2, nuclear-encoded CLP
protease P7		 -0.67 0.29 -0.33
5 AT4G09800 S18 ribosomal protein S18 ribosomal protein -0.67 0.33 -0.33
6 AT4G39200 Ribosomal protein S25 family protein -0.67 0.31 -0.33
7 AT5G65430 general regulatory factor 8 14-3-3 PROTEIN G-BOX FACTOR14
KAPPA, GF14 KAPPA, general
regulatory factor 8		 -0.67 0.33 -0.33
8 AT1G16870 mitochondrial 28S ribosomal protein S29-related -0.66 0.31 -0.32
9 AT1G49410 translocase of the outer mitochondrial membrane 6 translocase of the outer
mitochondrial membrane 6		 -0.66 0.3 -0.31
10 AT4G19960 K+ uptake permease 9 ATKUP9, HAK9, KT9, K+ uptake
permease 9		 0.66 0.31 -0.32
11 AT1G15250 Zinc-binding ribosomal protein family protein -0.65 0.3 -0.29
12 AT5G63140 purple acid phosphatase 29 purple acid phosphatase 29, PAP29,
purple acid phosphatase 29		 -0.65 0.31 -0.31
13 AT1G12310 Calcium-binding EF-hand family protein -0.64 0.32 -0.32
14 AT2G11890 adenylate cyclases -0.64 0.31 -0.3
15 AT5G40430 myb domain protein 22 myb domain protein 22, myb domain
protein 22		 -0.64 0.33 -0.31
16 AT5G14040 phosphate transporter 3;1 phosphate transporter 3;1 -0.63 0.31 -0.31
17 AT3G07630 arogenate dehydratase 2 arogenate dehydratase 2,
Arabidopsis thaliana arogenate
dehydratase 2		 -0.63 0.29 -0.32
18 AT3G52420 outer envelope membrane protein 7 OUTER ENVELOPE MEMBRANE PROTEIN 7,
outer envelope membrane protein 7		 -0.63 0.34 -0.33
19 AT5G11010 Pre-mRNA cleavage complex II protein family -0.63 0.33 -0.3
20 AT1G27310 nuclear transport factor 2A nuclear transport factor 2A -0.62 0.33 -0.34
21 AT3G26730 RING/U-box superfamily protein 0.62 0.34 -0.32
22 AT2G42310 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT3G57785.1); Has 115 Blast hits
to 115 proteins in 48 species: Archae - 0; Bacteria - 0;
Metazoa - 4; Fungi - 44; Plants - 67; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 -0.62 0.34 -0.31
23 AT4G37660 Ribosomal protein L12/ ATP-dependent Clp protease adaptor
protein ClpS family protein		 -0.62 0.33 -0.33
24 AT4G20870 fatty acid hydroxylase 2 ARABIDOPSIS FATTY ACID HYDROXYLASE
2, fatty acid hydroxylase 2		 -0.61 0.34 -0.31
25 AT5G56940 Ribosomal protein S16 family protein -0.61 0.33 -0.31
26 AT4G02230 Ribosomal protein L19e family protein -0.61 0.32 -0.32
27 AT2G21195 unknown protein; Has 28 Blast hits to 28 proteins in 11
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 28; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.61 0.32 -0.34
28 AT1G09510 NAD(P)-binding Rossmann-fold superfamily protein 0.61 0.34 -0.35
29 AT5G06770 KH domain-containing protein / zinc finger (CCCH type)
family protein		 -0.61 0.32 -0.3
30 AT5G53560 cytochrome B5 isoform E ATB5-A, ARABIDOPSIS CYTOCHROME B5
ISOFORM E, B5 #2, cytochrome B5
isoform E		 -0.61 0.32 -0.32
31 AT2G17710 unknown protein; Has 39 Blast hits to 39 proteins in 14
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 39; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.6 0.32 -0.33
32 AT5G58700 phosphatidylinositol-speciwc phospholipase C4 ATPLC4,
phosphatidylinositol-speciwc
phospholipase C4		 0.6 0.32 -0.32
33 AT1G50140 P-loop containing nucleoside triphosphate hydrolases
superfamily protein		 -0.6 0.32 -0.33
34 AT5G43150 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED
DURING: 13 growth stages; Has 1807 Blast hits to 1807
proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa
- 736; Fungi - 347; Plants - 385; Viruses - 0; Other
Eukaryotes - 339 (source: NCBI BLink).		 0.6 0.31 -0.32
35 AT2G37820 Cysteine/Histidine-rich C1 domain family protein -0.6 0.33 -0.31
36 AT5G42320 Zn-dependent exopeptidases superfamily protein -0.59 0.33 -0.3
37 AT4G25550 Cleavage/polyadenylation specificity factor, 25kDa subunit -0.59 0.3 -0.3
38 AT2G19660 Cysteine/Histidine-rich C1 domain family protein -0.59 0.31 -0.32
39 AT1G70900 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT1G23110.4); Has 57 Blast hits
to 57 proteins in 14 species: Archae - 0; Bacteria - 0;
Metazoa - 0; Fungi - 0; Plants - 57; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 0.59 0.32 -0.33
40 AT3G16100 RAB GTPase homolog G3C ATRAB7D, RAB GTPase homolog G3C,
RAB GTPase homolog G3C		 -0.59 0.32 -0.32
41 AT1G69560 myb domain protein 105 MYB DOMAIN PROTEIN 105, LATERAL
ORGAN FUSION 2, myb domain protein
105		 0.58 0.32 -0.32
42 AT3G15650 alpha/beta-Hydrolases superfamily protein 0.58 0.34 -0.32
43 AT2G15080 receptor like protein 19 receptor like protein 19, receptor
like protein 19		 0.58 0.32 -0.29
44 AT1G14510 alfin-like 7 alfin-like 7 -0.58 0.31 -0.33
45 AT3G26935 DHHC-type zinc finger family protein -0.57 0.3 -0.31
46 AT5G19180 E1 C-terminal related 1 E1 C-terminal related 1 -0.57 0.34 -0.31
47 AT3G11745 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED
DURING: 13 growth stages; Has 5 Blast hits to 5 proteins in
2 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi -
0; Plants - 5; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.57 0.32 -0.33
48 AT3G17430 Nucleotide-sugar transporter family protein -0.57 0.31 -0.33
49 AT2G18030 Peptide methionine sulfoxide reductase family protein -0.57 0.32 -0.32
50 AT3G04150 RmlC-like cupins superfamily protein 0.57 0.32 -0.3
51 AT1G12830 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
cellular_component unknown; EXPRESSED IN: 23 plant
structures; EXPRESSED DURING: 13 growth stages; Has 39778
Blast hits to 22088 proteins in 1060 species: Archae - 152;
Bacteria - 6161; Metazoa - 14109; Fungi - 6144; Plants -
2156; Viruses - 601; Other Eukaryotes - 10455 (source: NCBI
BLink).		 -0.57 0.33 -0.3
52 AT1G10000 Ribonuclease H-like superfamily protein 0.56 0.31 -0.32
53 AT3G01080 WRKY DNA-binding protein 58 WRKY DNA-BINDING PROTEIN 58, WRKY
DNA-binding protein 58		 0.56 0.3 -0.32
54 AT3G25160 ER lumen protein retaining receptor family protein 0.55 0.32 -0.32
55 AT5G18360 Disease resistance protein (TIR-NBS-LRR class) family 0.55 0.29 -0.3
Metabolite information
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  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
56 C0216 Proline L-Proline L-Proline proline degradation II,
arginine degradation VI (arginase 2 pathway),
L-Ndelta-acetylornithine biosynthesis,
tRNA charging,
citrulline biosynthesis,
proline biosynthesis III 		1 0.32 -0.29 C0216
57 C0057 Anthranilic acid - Anthranilate tryptophan biosynthesis,
benzoylanthranilate biosynthesis 		0.94 0.43 -0.47 C0057
58 C0015 p-Coumaric acid - 4-Coumarate scopoletin biosynthesis,
free phenylpropanoid acid biosynthesis,
phenylpropanoid biosynthesis,
simple coumarins biosynthesis,
4-hydroxybenzoate biosynthesis V,
suberin biosynthesis,
phenylpropanoid biosynthesis, initial reactions,
flavonoid biosynthesis 		0.9 0.44 -0.45 C0015
59 C0056 AMP - AMP PRPP biosynthesis I,
fatty acid biosynthesis (plant mitochondria),
adenine and adenosine salvage VI,
biotin-carboxyl carrier protein assembly,
molybdenum cofactor biosynthesis II (eukaryotes),
gluconeogenesis I,
adenine and adenosine salvage II,
asparagine biosynthesis I,
L-glutamine biosynthesis II (tRNA-dependent),
trans-cinnamoyl-CoA biosynthesis,
IAA degradation V,
ethanol degradation II (cytosol),
arginine biosynthesis I,
IAA degradation IV,
fatty acid activation,
selenate reduction,
IAA biosynthesis VII,
4-hydroxybenzoate biosynthesis V,
tetrapyrrole biosynthesis I,
flavonoid biosynthesis,
indole-3-acetyl-amino acid biosynthesis,
glutamine biosynthesis III,
ethanol degradation IV (peroxisomal),
glycolysis I,
asparagine biosynthesis III (tRNA-dependent),
jasmonoyl-amino acid conjugates biosynthesis I,
molybdenum cofactor biosynthesis,
pyridine nucleotide cycling (plants),
scopoletin biosynthesis,
jasmonic acid biosynthesis,
adenosine nucleotides degradation I,
fatty acid beta-oxidation II (core pathway),
simple coumarins biosynthesis,
sulfate reduction II (assimilatory),
pantothenate biosynthesis,
sporopollenin precursor biosynthesis,
urea cycle,
thiamine biosynthesis II,
starch degradation II,
NAD biosynthesis I (from aspartate),
citrulline-nitric oxide cycle,
beta-alanine biosynthesis II,
arginine biosynthesis II (acetyl cycle),
suberin biosynthesis,
linoleate biosynthesis I (plants),
trans-zeatin biosynthesis,
tetrahydrofolate biosynthesis II,
purine nucleotides de novo biosynthesis II,
phenylpropanoid biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
purine nucleotide metabolism (phosphotransfer and nucleotide modification),
tRNA charging 		0.83 0.44 -0.46 C0056
60 C0032 3-Phosphoglyceric acid 3-Phospho-(R)-glyceric acid 3-Phosphoglycerate glycolysis I,
gluconeogenesis I,
Calvin-Benson-Bassham cycle,
sucrose biosynthesis I,
serine biosynthesis,
photorespiration,
Rubisco shunt,
glycolysis IV (plant cytosol) 		0.77 0.45 -0.44 C0032
61 C0262 UDP-glucuronic acid - UDP-D-glucuronate xylan biosynthesis,
UDP-D-glucuronate biosynthesis (from myo-inositol),
UDP-D-galacturonate biosynthesis I (from UDP-D-glucuronate),
UDP-D-apiose biosynthesis (from UDP-D-glucuronate),
galactose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis 		0.73 0.44 -0.45 C0262
62 C0257 Tryptophan L-Tryptophan L-Tryptophan glucosinolate biosynthesis from tryptophan,
IAA biosynthesis I,
tryptophan biosynthesis,
camalexin biosynthesis,
tRNA charging 		0.72 0.3 -0.32 C0257
63 C0030 3-Methylsulfinyl-n-propylglucosinolate - 3-Methylsulfinylpropyl-glucosinolate glucosinolate biosynthesis from homomethionine 0.71 0.46 -0.43 C0030
64 C0260 Tyrosine L-(-)-Tyrosine L-Tyrosine tyrosine biosynthesis II,
4-hydroxyphenylpyruvate biosynthesis,
tyrosine degradation I,
tyrosine biosynthesis I,
tRNA charging,
hydroxycinnamic acid tyramine amides biosynthesis 		0.7 0.3 -0.32 C0260
65 C0052 Adenosine - Adenosine adenine and adenosine salvage VI,
S-adenosyl-L-methionine cycle II,
cytokinins degradation,
methionine degradation I (to homocysteine),
adenine and adenosine salvage II 		0.7 0.3 -0.29 C0052
66 C0087 Erythrose-4-phosphate D-Erythrose-4-phosphate D-Erythrose-4-phosphate Rubisco shunt,
pentose phosphate pathway (non-oxidative branch),
chorismate biosynthesis,
Calvin-Benson-Bassham cycle 		0.7 0.45 -0.47 C0087
67 C0099 Glucose-1-phosphate α,β-D-Glucose-1-phosphate α-D-Glucose-1-phosphate; β-D-Glucose-1-phosphate galactose degradation I (Leloir pathway) 0.7 0.44 -0.48 C0099
68 C0094 Galactosamine D-Galactosamine - - 0.7 0.45 -0.47
69 C0091 Fructose-1,6-bisphosphate D-Fructose-1,6-bisphosphate Fructose-1,6-bisphosphate gluconeogenesis I,
Calvin-Benson-Bassham cycle,
glycolysis IV (plant cytosol),
glycolysis I,
CA1P biosynthesis,
sucrose biosynthesis I 		0.69 0.46 -0.47 C0091
70 C0006 β-Homothreonine L-β-Homothreonine - - 0.69 0.44 -0.45
71 C0180 MST_2539.9 - - - 0.69 0.47 -0.43
72 C0193 Pantothenic acid D,L-Pantothenic acid Pantothenate pantothenate biosynthesis 0.68 0.44 -0.43 C0193
73 C0054 Agmatine - Agmatine putrescine biosynthesis I,
putrescine biosynthesis II,
superpathway of polyamine biosynthesis 		0.68 0.33 -0.3 C0054
74 C0061 Aspartic acid L-Aspartic acid L-Aspartate purine nucleotide metabolism (phosphotransfer and nucleotide modification),
tRNA charging,
indole-3-acetyl-amino acid biosynthesis,
citrulline-nitric oxide cycle,
asparagine degradation I,
cyanide detoxification II,
asparagine biosynthesis I,
asparagine biosynthesis III (tRNA-dependent),
arginine biosynthesis I,
inosine-5'-phosphate biosynthesis II,
uridine-5'-phosphate biosynthesis,
aspartate biosynthesis,
homoserine biosynthesis,
lysine biosynthesis VI,
aspartate degradation II,
urea cycle,
purine nucleotides de novo biosynthesis II,
NAD biosynthesis I (from aspartate),
IAA degradation IV,
arginine biosynthesis II (acetyl cycle) 		0.67 0.31 -0.32 C0061
75 C0137 Leucine L-Leucine L-Leucine indole-3-acetyl-amino acid biosynthesis,
leucine biosynthesis,
jasmonoyl-amino acid conjugates biosynthesis I,
IAA biosynthesis II,
tRNA charging,
leucine degradation I 		0.67 0.32 -0.31 C0137
76 C0062 Betain - - - 0.67 0.33 -0.33
77 C0011 N-Acetyl-glutamic acid N-Acetyl-D,L-glutamic acid N-Acetyl-L-glutamate arginine biosynthesis II (acetyl cycle),
ornithine biosynthesis 		0.67 0.45 -0.46 C0011
78 C0261 UDP-glucose - UDP-D-glucose quercetin glucoside biosynthesis (Arabidopsis),
abscisic acid glucose ester biosynthesis,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
UDP-glucose biosynthesis (from sucrose),
2,4,6-trinitrotoluene degradation,
galactose degradation I (Leloir pathway),
cytokinins-O-glucoside biosynthesis,
trehalose biosynthesis I,
dolichyl-diphosphooligosaccharide biosynthesis,
phenolic malonylglucosides biosynthesis,
callose biosynthesis,
superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside),
glucosinolate biosynthesis from hexahomomethionine,
coniferin metabolism,
glucosinolate biosynthesis from phenylalanine,
xyloglucan biosynthesis,
glucosinolate biosynthesis from pentahomomethionine,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
glucosinolate biosynthesis from dihomomethionine,
cellulose biosynthesis,
sinapate ester biosynthesis,
superpathway of IAA conjugate biosynthesis,
salicylate glucosides biosynthesis IV,
sucrose biosynthesis I,
glucosinolate biosynthesis from trihomomethionine,
tetrahydrofolate biosynthesis II,
sucrose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis,
coumarin biosynthesis (via 2-coumarate),
superpathway of sucrose and starch metabolism I (non-photosynthetic tissue),
monolignol glucosides biosynthesis,
glucosinolate biosynthesis from homomethionine,
kaempferol glucoside biosynthesis (Arabidopsis),
salicylate glucosides biosynthesis III,
cytokinins 7-N-glucoside biosynthesis,
galactose degradation III,
cytokinins 9-N-glucoside biosynthesis,
glucosinolate biosynthesis from tryptophan,
UDP-galactose biosynthesis,
salicylate glucosides biosynthesis II,
stachyose degradation,
superpathway of sucrose and starch metabolism II (photosynthetic tissue),
UDP-glucose biosynthesis (from glucose 6-phosphate),
sphingolipid biosynthesis (plants),
glucosinolate biosynthesis from tetrahomomethionine,
galactose degradation II,
UDP-L-rhamnose biosynthesis 		0.67 0.45 -0.43 C0261
79 C0259 Tyramine - Tyramine hydroxycinnamic acid tyramine amides biosynthesis,
suberin biosynthesis 		0.66 0.31 -0.3 C0259
80 C0088 FAD - FAD cytokinins degradation,
lysine degradation II,
valine degradation I,
isoleucine degradation I,
flavin biosynthesis I (bacteria and plants) 		0.66 0.45 -0.47 C0088
81 C0130 Kaempferol-3-O-α-rhamnopyranosyl(1,2)-β-glucopyranoside-7-O-α-rhamnopyranoside Kaempferol-3-O-α-L-rhamnopyranosyl(1,2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside - 0.65 0.46 -0.45
82 C0066 Choline - Choline choline biosynthesis III,
phosphatidylcholine biosynthesis I,
choline biosynthesis I,
glycine betaine biosynthesis III (plants),
choline biosynthesis II,
sinapate ester biosynthesis,
phospholipases 		0.65 0.32 -0.32 C0066
83 C0075 dGDP - dGDP purine nucleotide metabolism (phosphotransfer and nucleotide modification) 0.65 0.44 -0.43 C0075
84 C0073 Cysteine L-Cysteine L-Cysteine alanine biosynthesis III,
cysteine biosynthesis I,
gamma-glutamyl cycle (plant pathway),
farnesylcysteine salvage pathway,
molybdenum cofactor biosynthesis,
thiamine biosynthesis II,
cyanide detoxification II,
indole glucosinolate breakdown (insect chewing induced),
glutathione degradation,
glutathione biosynthesis,
molybdenum cofactor biosynthesis II (eukaryotes),
cyanide degradation,
homocysteine and cysteine interconversion,
methionine biosynthesis II,
tRNA charging,
gamma-glutamyl cycle,
coenzyme A biosynthesis 		0.63 0.46 -0.45 C0073
85 C0218 Pyridoxamine phosphate Pyridoxamine-5'-phosphate Pyridoxamine-5'-phosphate pyridoxal 5'-phosphate salvage pathway 0.62 0.32 -0.32 C0218
86 C0005 β-Fructose-6-phosphate β-D-Fructose-6-phosphate D-Fructose-6-phosphate starch biosynthesis,
Rubisco shunt,
Calvin-Benson-Bassham cycle,
mannitol degradation II,
ascorbate biosynthesis I (L-galactose pathway),
UDP-N-acetyl-D-glucosamine biosynthesis II,
GDP-mannose biosynthesis,
mannose degradation,
sucrose biosynthesis I,
sucrose degradation III,
glycolysis IV (plant cytosol),
pentose phosphate pathway (non-oxidative branch),
glycolysis I,
superpathway of sucrose and starch metabolism II (photosynthetic tissue),
D-mannose degradation,
gluconeogenesis I 		0.61 0.31 -0.35 C0005
87 C0068 Citric acid - Citrate acetyl-CoA biosynthesis (from citrate),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
glutamine biosynthesis III,
glyoxylate cycle 		0.6 0.31 -0.32 C0068
88 C0113 Histidinol - Histidinol histidine biosynthesis 0.59 0.32 -0.32 C0113
89 C0022 1,4-Butanediamine - Putrescine spermine and spermidine degradation III,
putrescine degradation IV,
superpathway of polyamine biosynthesis,
putrescine biosynthesis II,
spermidine biosynthesis I,
putrescine biosynthesis I 		0.58 0.31 -0.31 C0022
90 C0112 Histidine L-Histidine L-Histidine tRNA charging,
histidine biosynthesis 		0.57 0.31 -0.34 C0112
91 C0140 Lysine L-Lysine L-Lysine lysine degradation II,
tRNA charging,
lysine biosynthesis VI,
lysine degradation I 		0.56 0.33 -0.34 C0140