C0026 : 2-Hydroxyisobutyric acid
Query Information
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ID C0026
Compound name 2-Hydroxyisobutyric acid
External link -
Pathway Information β oxidation
Gene information
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  Gene Code Description / Information Gene name Correlation link
pcc 2.5% 97.5% PPI
1 AT5G19200 NAD(P)-binding Rossmann-fold superfamily protein TSC10B 0.85 0.47 -0.47
2 AT1G53980 Ubiquitin-like superfamily protein 0.83 0.45 -0.46
3 AT1G11930 Predicted pyridoxal phosphate-dependent enzyme, YBL036C
type		 0.82 0.42 -0.46
4 AT3G56240 copper chaperone copper chaperone 0.82 0.43 -0.43
5 AT1G56710 Pectin lyase-like superfamily protein 0.81 0.46 -0.47
6 AT3G22250 UDP-Glycosyltransferase superfamily protein 0.81 0.47 -0.45
7 AT5G51720 2 iron, 2 sulfur cluster binding -0.81 0.44 -0.44
8 AT3G52170 DNA binding -0.8 0.44 -0.45
9 AT2G42700 FUNCTIONS IN: molecular_function unknown; INVOLVED IN:
vesicle-mediated transport, vesicle docking involved in
exocytosis; LOCATED IN: cellular_component unknown;
EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14
growth stages; CONTAINS InterPro DOMAIN/s: Sec1-like
protein (InterPro:IPR001619); Has 30201 Blast hits to 17322
proteins in 780 species: Archae - 12; Bacteria - 1396;
Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0;
Other Eukaryotes - 2996 (source: NCBI BLink).		 0.8 0.43 -0.43
10 AT5G02220 unknown protein; Has 30201 Blast hits to 17322 proteins in
780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338;
Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes
- 2996 (source: NCBI BLink).		 -0.8 0.45 -0.42
11 AT1G60030 nucleobase-ascorbate transporter 7 ARABIDOPSIS NUCLEOBASE-ASCORBATE
TRANSPORTER 7,
nucleobase-ascorbate transporter 7		 -0.8 0.42 -0.46
12 AT4G26150 cytokinin-responsive gata factor 1 cytokinin-responsive gata factor
1, GATA TRANSCRIPTION FACTOR 22,
GNC-LIKE		 -0.79 0.44 -0.45
13 AT2G40300 ferritin 4 ferritin 4, ferritin 4 -0.79 0.45 -0.45
14 AT1G19200 Protein of unknown function (DUF581) 0.78 0.45 -0.41
15 AT4G13160 Protein of unknown function, DUF593 0.78 0.43 -0.46
16 AT3G11930 Adenine nucleotide alpha hydrolases-like superfamily
protein		 0.78 0.45 -0.43
17 AT1G49840 Protein of unknown function (DUF620) -0.78 0.43 -0.44
18 AT1G63680 acid-amino acid ligases;ligases;ATP binding;ATP
binding;ligases		 ALBINO OR PALE-GREEN 13, ATMURE,
MURE, PIGMENT DEFECTIVE EMBRYO 316		 -0.77 0.42 -0.44
19 AT1G76880 Duplicated homeodomain-like superfamily protein -0.77 0.43 -0.45
20 AT4G24400 CBL-interacting protein kinase 8 ATCIPK8, CBL-interacting protein
kinase 8, PROTEIN KINASE 11,
SNF1-RELATED PROTEIN KINASE 3.13		 0.77 0.45 -0.47
21 AT5G46340 O-acetyltransferase family protein REDUCED WALL ACETYLATION 1 0.77 0.47 -0.47
22 AT5G23640 unknown protein; Has 1807 Blast hits to 1807 proteins in
277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi
- 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339
(source: NCBI BLink).		 0.76 0.45 -0.47
23 AT3G43660 Vacuolar iron transporter (VIT) family protein -0.76 0.43 -0.42
24 AT4G16460 unknown protein; Has 58 Blast hits to 58 proteins in 23
species: Archae - 0; Bacteria - 0; Metazoa - 30; Fungi - 4;
Plants - 16; Viruses - 0; Other Eukaryotes - 8 (source:
NCBI BLink).		 0.76 0.41 -0.45
25 AT2G22740 SU(VAR)3-9 homolog 6 SET DOMAIN PROTEIN 23, SU(VAR)3-9
homolog 6		 0.76 0.43 -0.46
26 AT1G55915 zinc ion binding -0.74 0.44 -0.45
27 AT2G06700 transposable element gene 0.74 0.43 -0.44
28 AT4G32120 Galactosyltransferase family protein -0.74 0.43 -0.47
29 AT4G19470 Leucine-rich repeat (LRR) family protein -0.74 0.46 -0.44
30 AT5G59130 Subtilase family protein -0.74 0.42 -0.49
31 AT5G05930 guanylyl cyclase 1 ARABIDOPSIS GUANYLYL CYCLASE 1,
guanylyl cyclase 1		 0.74 0.41 -0.44
32 AT2G32280 Protein of unknown function (DUF1218) -0.74 0.47 -0.43
33 AT5G21060 Glyceraldehyde-3-phosphate dehydrogenase-like family
protein		 0.73 0.42 -0.42
34 AT2G21800 essential meiotic endonuclease 1A essential meiotic endonuclease 1A,
EME1A, essential meiotic
endonuclease 1A		 -0.73 0.42 -0.45
35 AT2G32080 purin-rich alpha 1 purin-rich alpha 1 0.73 0.45 -0.45
36 AT4G01910 Cysteine/Histidine-rich C1 domain family protein 0.73 0.43 -0.45
37 AT1G11630 Tetratricopeptide repeat (TPR)-like superfamily protein 0.73 0.46 -0.45
38 AT3G13470 TCP-1/cpn60 chaperonin family protein chaperonin-60beta2 -0.73 0.47 -0.44
39 AT5G07850 HXXXD-type acyl-transferase family protein 0.73 0.43 -0.44
40 AT2G04520 Nucleic acid-binding, OB-fold-like protein -0.73 0.44 -0.45
41 AT1G13380 Protein of unknown function (DUF1218) -0.73 0.43 -0.44
42 AT5G40430 myb domain protein 22 myb domain protein 22, myb domain
protein 22		 -0.73 0.42 -0.47
43 AT5G03270 lysine decarboxylase family protein LONELY GUY 6 0.73 0.41 -0.44
44 AT1G44770 unknown protein; BEST Arabidopsis thaliana protein match
is: unknown protein (TAIR:AT5G49710.3); Has 81 Blast hits
to 81 proteins in 17 species: Archae - 0; Bacteria - 0;
Metazoa - 0; Fungi - 0; Plants - 81; Viruses - 0; Other
Eukaryotes - 0 (source: NCBI BLink).		 0.72 0.45 -0.45
45 AT1G05300 zinc transporter 5 precursor zinc transporter 5 precursor -0.72 0.46 -0.45
46 AT3G21470 Pentatricopeptide repeat (PPR-like) superfamily protein -0.72 0.43 -0.48
47 AT4G13980 winged-helix DNA-binding transcription factor family
protein		 AT-HSFA5, HEAT SHOCK TRANSCRIPTION
FACTOR A5		 0.72 0.43 -0.47
48 AT3G57860 UV-B-insensitive 4-like GIGAS CELL 1, OMISSION OF SECOND
DIVISION, UV-B-insensitive 4-like		 -0.72 0.45 -0.43
49 AT3G22740 homocysteine S-methyltransferase 3 homocysteine S-methyltransferase 3 0.72 0.45 -0.46
50 AT4G24020 NIN like protein 7 NIN like protein 7 0.72 0.45 -0.44
51 AT5G14510 ARM repeat superfamily protein 0.72 0.42 -0.46
52 AT2G27970 CDK-subunit 2 CDK-subunit 2 -0.72 0.43 -0.43
53 AT1G48800 Terpenoid cyclases/Protein prenyltransferases superfamily
protein		 -0.72 0.45 -0.44
54 AT5G39980 Tetratricopeptide repeat (TPR)-like superfamily protein -0.72 0.43 -0.49
55 AT4G01450 nodulin MtN21 /EamA-like transporter family protein 0.72 0.46 -0.43
56 AT4G12890 Gamma interferon responsive lysosomal thiol (GILT)
reductase family protein		 -0.71 0.43 -0.41
57 ATMG00890 hypothetical protein ORF106D 0.71 0.44 -0.44
58 AT1G55520 TATA binding protein 2 A. THALIANA TATA BINDING PROTEIN
2, TATA binding protein 2		 0.71 0.44 -0.43
59 AT3G10730 SAD1/UNC-84 domain protein 2 ARABIDOPSIS SAD1/UNC-84 DOMAIN
PROTEIN 2, SAD1/UNC-84 domain
protein 2		 -0.71 0.46 -0.46
60 AT5G05700 arginine-tRNA protein transferase 1 ATATE1, arginine-tRNA protein
transferase 1, DELAYED LEAF
SENESCENCE 1		 0.71 0.42 -0.43
61 AT5G65410 homeobox protein 25 ARABIDOPSIS THALIANA HOMEOBOX
PROTEIN 25, homeobox protein 25,
ZINC FINGER HOMEODOMAIN 2, ZINC
FINGER HOMEODOMAIN 1		 -0.71 0.43 -0.43
62 AT4G23590 Tyrosine transaminase family protein 0.71 0.47 -0.46
63 AT1G69700 HVA22 homologue C HVA22 homologue C, HVA22 homologue
C		 -0.71 0.43 -0.45
64 AT5G55250 IAA carboxylmethyltransferase 1 AtIAMT1, IAA
carboxylmethyltransferase 1		 -0.71 0.46 -0.48
65 AT3G25160 ER lumen protein retaining receptor family protein 0.71 0.46 -0.46
66 AT5G47600 HSP20-like chaperones superfamily protein -0.71 0.43 -0.44
67 AT4G24240 WRKY DNA-binding protein 7 ATWRKY7, WRKY DNA-binding protein
7		 -0.71 0.41 -0.42
68 AT5G58670 phospholipase C1 ARABIDOPSIS THALIANA PHOSPHOLIPASE
C, phospholipase C1, phospholipase
C 1, phospholipase C1		 0.71 0.43 -0.43
69 AT2G47630 alpha/beta-Hydrolases superfamily protein -0.71 0.46 -0.45
70 AT5G22875 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
endomembrane system; EXPRESSED IN: 24 plant structures;
EXPRESSED DURING: 15 growth stages; Has 30201 Blast hits to
17322 proteins in 780 species: Archae - 12; Bacteria -
1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses
- 0; Other Eukaryotes - 2996 (source: NCBI BLink).		 -0.71 0.43 -0.47
71 AT3G56090 ferritin 3 ferritin 3, ferritin 3 -0.71 0.43 -0.46
72 AT5G06670 P-loop containing nucleoside triphosphate hydrolases
superfamily protein		 -0.7 0.45 -0.45
73 AT3G19780 LOCATED IN: endomembrane system; CONTAINS InterPro
DOMAIN/s: Protein of unknown function DUF179
(InterPro:IPR003774), Thioredoxin fold
(InterPro:IPR012335), Thioredoxin-like fold
(InterPro:IPR012336); BEST Arabidopsis thaliana protein
match is: Protein of unknown function (DUF179)
(TAIR:AT1G33780.1); Has 74 Blast hits to 72 proteins in 32
species: Archae - 0; Bacteria - 24; Metazoa - 11; Fungi -
3; Plants - 32; Viruses - 0; Other Eukaryotes - 4 (source:
NCBI BLink).		 -0.7 0.47 -0.43
74 AT2G47010 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
endomembrane system; EXPRESSED IN: 17 plant structures;
EXPRESSED DURING: 10 growth stages; BEST Arabidopsis
thaliana protein match is: unknown protein
(TAIR:AT1G17030.1); Has 72 Blast hits to 72 proteins in 13
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 71; Viruses - 0; Other Eukaryotes - 1 (source:
NCBI BLink).		 -0.7 0.43 -0.42
75 AT3G49360 6-phosphogluconolactonase 2 6-phosphogluconolactonase 2 -0.7 0.44 -0.46
76 AT3G48610 non-specific phospholipase C6 non-specific phospholipase C6 -0.7 0.45 -0.43
77 AT1G35290 Thioesterase superfamily protein -0.7 0.45 -0.45
78 AT3G28310 Protein of unknown function (DUF677) -0.7 0.45 -0.43
79 AT3G16050 pyridoxine biosynthesis 1.2 A37, ARABIDOPSIS THALIANA
PYRIDOXINE BIOSYNTHESIS 1.2,
pyridoxine biosynthesis 1.2		 -0.7 0.45 -0.43
80 AT2G20100 basic helix-loop-helix (bHLH) DNA-binding superfamily
protein		 -0.7 0.45 -0.45
81 AT5G54720 Ankyrin repeat family protein -0.7 0.5 -0.43
82 AT1G79650 Rad23 UV excision repair protein family Arabidopsis thaliana aldehyde
oxidase 1, RADIATION SENSITIVE23B		 -0.7 0.44 -0.45
83 AT4G15330 cytochrome P450, family 705, subfamily A, polypeptide 1 cytochrome P450, family 705,
subfamily A, polypeptide 1		 0.7 0.47 -0.46
84 AT1G13130 Cellulase (glycosyl hydrolase family 5) protein -0.7 0.44 -0.47
85 AT1G19310 RING/U-box superfamily protein 0.69 0.45 -0.48
86 AT3G04230 Ribosomal protein S5 domain 2-like superfamily protein -0.69 0.46 -0.43
87 AT3G61840 Protein of unknown function (DUF688) 0.69 0.43 -0.44
88 AT5G42600 marneral synthase marneral synthase 0.69 0.46 -0.44
89 AT1G06970 cation/hydrogen exchanger 14 ATCHX14, cation/hydrogen exchanger
14		 -0.69 0.44 -0.49
90 AT5G24850 cryptochrome 3 cryptochrome 3 -0.69 0.44 -0.43
91 AT3G27530 golgin candidate 6 golgin candidate 6, MAIGO 4 0.69 0.45 -0.47
92 AT3G19540 Protein of unknown function (DUF620) -0.69 0.44 -0.42
93 AT1G62830 LSD1-like 1 ARABIDOPSIS LYSINE-SPECIFIC
HISTONE DEMETHYLASE, ATSWP1,
LSD1-like 1, LYSINE-SPECIFIC
HISTONE DEMETHYLASE, SWP1		 -0.69 0.44 -0.44
94 AT5G17720 alpha/beta-Hydrolases superfamily protein -0.69 0.44 -0.45
95 AT5G02180 Transmembrane amino acid transporter family protein -0.69 0.44 -0.44
96 AT3G48710 DEK domain-containing chromatin associated protein 0.69 0.44 -0.45
97 AT1G31430 Pentatricopeptide repeat (PPR-like) superfamily protein -0.69 0.45 -0.44
98 AT2G14460 unknown protein; Has 3 Blast hits to 3 proteins in 1
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 3; Viruses - 0; Other Eukaryotes - 0 (source: NCBI
BLink).		 -0.69 0.46 -0.44
99 AT2G07230 transposable element gene 0.69 0.46 -0.43
100 AT1G14530 Protein of unknown function (DUF1084) TOM THREE HOMOLOG 1 0.69 0.45 -0.44
101 AT5G65420 CYCLIN D4;1 CYCLIN D4;1 -0.69 0.44 -0.46
102 AT4G18990 xyloglucan endotransglucosylase/hydrolase 29 xyloglucan
endotransglucosylase/hydrolase 29		 0.69 0.44 -0.46
103 AT1G23560 Domain of unknown function (DUF220) 0.68 0.46 -0.44
104 AT3G48900 single-stranded DNA endonuclease family protein -0.68 0.43 -0.48
105 AT4G35090 catalase 2 catalase 2 -0.68 0.44 -0.44
106 AT1G79890 RAD3-like DNA-binding helicase protein -0.68 0.44 -0.4
107 AT5G46270 Disease resistance protein (TIR-NBS-LRR class) family -0.68 0.43 -0.44
108 AT3G61850 Dof-type zinc finger DNA-binding family protein dof affecting germination 1 0.68 0.44 -0.43
109 AT4G16120 COBRA-like protein-7 precursor ARABIDOPSIS THALIANA SEC61 BETA 1,
COBRA-like protein-7 precursor,
SEC61 BETA 1		 -0.68 0.44 -0.48
110 AT3G16870 GATA transcription factor 17 GATA transcription factor 17 -0.68 0.44 -0.41
111 AT5G11470 bromo-adjacent homology (BAH) domain-containing protein -0.68 0.46 -0.46
112 AT5G57180 chloroplast import apparatus 2 chloroplast import apparatus 2 -0.68 0.42 -0.44
113 AT4G25540 homolog of DNA mismatch repair protein MSH3 ATMSH3, homolog of DNA mismatch
repair protein MSH3		 -0.68 0.44 -0.44
114 AT5G54800 glucose 6-phosphate/phosphate translocator 1 ARABIDOPSIS GLUCOSE
6-PHOSPHATE/PHOSPHATE TRANSLOCATOR
1, glucose 6-phosphate/phosphate
translocator 1		 0.68 0.44 -0.46
115 AT1G13110 cytochrome P450, family 71 subfamily B, polypeptide 7 cytochrome P450, family 71
subfamily B, polypeptide 7		 -0.68 0.47 -0.42
116 AT1G14350 Duplicated homeodomain-like superfamily protein myb domain protein 124, FOUR LIPS,
MYB124		 -0.68 0.44 -0.46
117 AT1G19230 Riboflavin synthase-like superfamily protein 0.68 0.44 -0.47
118 AT1G73660 protein tyrosine kinase family protein -0.68 0.43 -0.48
119 AT5G46760 Basic helix-loop-helix (bHLH) DNA-binding family protein MYC3 0.68 0.47 -0.45
120 AT1G27880 DEAD/DEAH box RNA helicase family protein -0.68 0.44 -0.44
121 AT2G44525 Protein of unknown function (DUF498/DUF598) 0.67 0.45 -0.43
122 AT1G15510 Tetratricopeptide repeat (TPR)-like superfamily protein ARABIDOPSIS EARLY CHLOROPLAST
BIOGENESIS2, EARLY CHLOROPLAST
BIOGENESIS2, VANILLA CREAM 1		 -0.67 0.41 -0.43
123 AT3G47590 alpha/beta-Hydrolases superfamily protein 0.67 0.41 -0.47
124 AT2G33320 Calcium-dependent lipid-binding (CaLB domain) family
protein		 -0.67 0.47 -0.46
125 AT3G02340 RING/U-box superfamily protein 0.67 0.48 -0.43
126 AT2G27200 P-loop containing nucleoside triphosphate hydrolases
superfamily protein		 0.67 0.48 -0.45
127 AT2G34840 Coatomer epsilon subunit 0.67 0.42 -0.44
128 AT5G19150 pfkB-like carbohydrate kinase family protein 0.67 0.43 -0.41
129 AT4G38100 unknown protein; LOCATED IN: chloroplast thylakoid
membrane; EXPRESSED IN: 23 plant structures; EXPRESSED
DURING: 13 growth stages; BEST Arabidopsis thaliana protein
match is: unknown protein (TAIR:AT4G01150.1); Has 30201
Blast hits to 17322 proteins in 780 species: Archae - 12;
Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants -
5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI
BLink).		 -0.67 0.45 -0.43
130 AT2G19510 LOB domain-containing protein 8 LOB domain-containing protein 8 0.67 0.44 -0.43
131 AT4G13780 methionine--tRNA ligase, putative / methionyl-tRNA
synthetase, putative / MetRS, putative		 0.67 0.44 -0.42
132 AT3G10700 galacturonic acid kinase galacturonic acid kinase -0.67 0.44 -0.44
133 AT1G10000 Ribonuclease H-like superfamily protein 0.67 0.47 -0.43
134 AT5G49160 methyltransferase 1 DECREASED DNA METHYLATION 2, DNA
METHYLTRANSFERASE 01, DNA
METHYLTRANSFERASE 1,
methyltransferase 1,
METHYLTRANSFERASE 2,
METHYLTRANSFERASE I		 -0.67 0.42 -0.45
135 AT1G71770 poly(A)-binding protein 5 poly(A)-binding protein 5 -0.67 0.46 -0.45
136 AT5G17170 rubredoxin family protein enhancer of sos3-1 -0.67 0.42 -0.41
137 AT1G56510 Disease resistance protein (TIR-NBS-LRR class) ACTIVATED DISEASE RESISTANCE 2,
WHITE RUST RESISTANCE 4		 -0.67 0.46 -0.46
138 AT4G16270 Peroxidase superfamily protein 0.67 0.43 -0.45
139 AT2G36835 unknown protein; FUNCTIONS IN: molecular_function unknown;
INVOLVED IN: biological_process unknown; LOCATED IN:
chloroplast envelope; EXPRESSED IN: 22 plant structures;
EXPRESSED DURING: 13 growth stages; Has 26 Blast hits to 26
proteins in 11 species: Archae - 0; Bacteria - 0; Metazoa -
0; Fungi - 0; Plants - 26; Viruses - 0; Other Eukaryotes -
0 (source: NCBI BLink).		 -0.67 0.43 -0.46
140 AT3G06660 PAPA-1-like family protein / zinc finger (HIT type) family
protein		 -0.67 0.44 -0.46
141 AT2G32220 Ribosomal L27e protein family -0.67 0.44 -0.43
142 AT5G62070 IQ-domain 23 IQ-domain 23 -0.67 0.44 -0.42
143 AT2G30590 WRKY DNA-binding protein 21 WRKY DNA-binding protein 21 -0.67 0.43 -0.43
144 AT4G32160 Phox (PX) domain-containing protein 0.67 0.42 -0.43
145 AT1G63810 CONTAINS InterPro DOMAIN/s: Nrap protein
(InterPro:IPR005554); Has 396 Blast hits to 382 proteins in
182 species: Archae - 3; Bacteria - 2; Metazoa - 142; Fungi
- 146; Plants - 43; Viruses - 0; Other Eukaryotes - 60
(source: NCBI BLink).		 -0.66 0.44 -0.45
146 AT5G24840 tRNA (guanine-N-7) methyltransferase -0.66 0.45 -0.46
147 AT3G43670 Copper amine oxidase family protein -0.66 0.46 -0.44
148 AT5G16690 origin recognition complex subunit 3 ATORC3, origin recognition complex
subunit 3		 -0.66 0.46 -0.45
149 AT3G59220 pirin ATPIRIN1, pirin, PRN1 -0.66 0.43 -0.43
150 AT3G27520 unknown protein; Has 28 Blast hits to 28 proteins in 10
species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0;
Plants - 28; Viruses - 0; Other Eukaryotes - 0 (source:
NCBI BLink).		 -0.66 0.42 -0.46
151 AT5G24690 Protein of unknown function (DUF3411) -0.66 0.49 -0.43
152 AT5G27700 Ribosomal protein S21e -0.66 0.41 -0.44
153 AT1G80000 CASC3/Barentsz eIF4AIII binding -0.66 0.43 -0.45
Metabolite information
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  CID Metabolite name Pathway Information Correlation link
Compound name Stereochemistry Aracyc name pcc 2.5% 97.5% PPI
154 C0026 2-Hydroxyisobutyric acid - - β oxidation 1 0.48 -0.42
155 C0243 Succinic acid - Succinate flavonol biosynthesis,
glyoxylate cycle,
gibberellin biosynthesis III (early C-13 hydroxylation),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
aerobic respiration (alternative oxidase pathway),
gibberellin inactivation I (2beta-hydroxylation),
4-aminobutyrate degradation IV,
luteolin biosynthesis,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
leucodelphinidin biosynthesis,
glutamate degradation IV,
gibberellin biosynthesis I (non C-3, non C-13 hydroxylation),
succinate + a ubiquinone -> a ubiquinol + fumarate,
gibberellin biosynthesis II (early C-3 hydroxylation),
flavonoid biosynthesis,
superpathway of glyoxylate cycle and fatty acid degradation,
aerobic respiration (cytochrome c),
leucopelargonidin and leucocyanidin biosynthesis,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
scopoletin biosynthesis 		0.94 0.44 -0.46 C0243
156 C0068 Citric acid - Citrate acetyl-CoA biosynthesis (from citrate),
TCA cycle variation V (plant),
TCA cycle variation III (eukaryotic),
glutamine biosynthesis III,
glyoxylate cycle 		0.89 0.45 -0.43 C0068
157 C0260 Tyrosine L-(-)-Tyrosine L-Tyrosine tyrosine biosynthesis II,
4-hydroxyphenylpyruvate biosynthesis,
tyrosine degradation I,
tyrosine biosynthesis I,
tRNA charging,
hydroxycinnamic acid tyramine amides biosynthesis 		0.87 0.45 -0.44 C0260
158 C0220 Pyruvic acid - Pyruvate sucrose degradation to ethanol and lactate (anaerobic),
alanine degradation II (to D-lactate),
alanine degradation III,
glutamine biosynthesis III,
pyruvate fermentation to ethanol II,
serine racemization,
methylerythritol phosphate pathway,
1,4-dihydroxy-2-naphthoate biosynthesis II (plants),
valine biosynthesis,
seleno-amino acid biosynthesis,
phenylalanine degradation III,
an electron-transfer-related quinone + D-lactate -> an electron-transfer-related quinol + pyruvate,
tetrahydrofolate biosynthesis II,
methylglyoxal degradation I,
glycolysis I,
tryptophan biosynthesis,
salicylate biosynthesis I,
pyruvate fermentation to lactate,
methionine biosynthesis II,
glutathione-mediated detoxification II,
IAA biosynthesis I,
TCA cycle variation V (plant),
Rubisco shunt,
gluconeogenesis I,
acetaldehyde biosynthesis I,
homocysteine and cysteine interconversion,
glycolysis IV (plant cytosol),
4-aminobutyrate degradation IV,
beta-alanine biosynthesis II,
isoleucine biosynthesis I (from threonine),
glutamate degradation IV,
lysine biosynthesis VI,
acetyl-CoA biosynthesis (from pyruvate),
alanine biosynthesis II 		0.85 0.43 -0.42 C0220
159 C0027 2-Oxoglutaric acid - α-Ketoglutarate gibberellin biosynthesis III (early C-13 hydroxylation),
leucopelargonidin and leucocyanidin biosynthesis,
aspartate degradation II,
ornithine biosynthesis,
isoleucine biosynthesis I (from threonine),
pantothenate biosynthesis,
phenylalanine degradation III,
flavonol biosynthesis,
lysine biosynthesis VI,
luteolin biosynthesis,
ammonia assimilation cycle II,
serine biosynthesis,
flavonoid biosynthesis,
glutamate biosynthesis V,
aspartate biosynthesis,
glutamate degradation I,
gibberellin inactivation I (2beta-hydroxylation),
alanine degradation III,
photorespiration,
valine biosynthesis,
glycine biosynthesis,
arginine biosynthesis II (acetyl cycle),
arginine degradation I (arginase pathway),
gibberellin biosynthesis II (early C-3 hydroxylation),
leucine biosynthesis,
glutamate biosynthesis IV,
tyrosine biosynthesis II,
proline biosynthesis III,
citrulline biosynthesis,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
L-Ndelta-acetylornithine biosynthesis,
isoleucine degradation I,
alanine biosynthesis II,
tyrosine biosynthesis I,
TCA cycle variation III (eukaryotic),
leucine degradation I,
alanine degradation II (to D-lactate),
TCA cycle variation V (plant),
arginine degradation VI (arginase 2 pathway),
valine degradation I,
gibberellin biosynthesis I (non C-3, non C-13 hydroxylation),
1,4-dihydroxy-2-naphthoate biosynthesis II (plants),
2-ketoglutarate dehydrogenase complex,
glutamate degradation IV,
tyrosine degradation I,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
IAA biosynthesis I,
phenylalanine biosynthesis II,
lysine degradation II,
scopoletin biosynthesis,
4-hydroxyphenylpyruvate biosynthesis,
histidine biosynthesis,
glutamine biosynthesis III,
leucodelphinidin biosynthesis 		0.85 0.42 -0.45 C0027
160 C0142 Malonic acid - Malonate fatty acid biosynthesis (plant mitochondria) 0.84 0.43 -0.43 C0142
161 C0218 Pyridoxamine phosphate Pyridoxamine-5'-phosphate Pyridoxamine-5'-phosphate pyridoxal 5'-phosphate salvage pathway 0.83 0.44 -0.44 C0218
162 C0014 O-Acetylserine O-Acetyl-L-serine O-Acetyl-L-serine cysteine biosynthesis I,
seleno-amino acid biosynthesis 		0.83 0.44 -0.41 C0014
163 C0091 Fructose-1,6-bisphosphate D-Fructose-1,6-bisphosphate Fructose-1,6-bisphosphate gluconeogenesis I,
Calvin-Benson-Bassham cycle,
glycolysis IV (plant cytosol),
glycolysis I,
CA1P biosynthesis,
sucrose biosynthesis I 		0.81 0.43 -0.45 C0091
164 C0054 Agmatine - Agmatine putrescine biosynthesis I,
putrescine biosynthesis II,
superpathway of polyamine biosynthesis 		0.79 0.47 -0.44 C0054
165 C0257 Tryptophan L-Tryptophan L-Tryptophan glucosinolate biosynthesis from tryptophan,
IAA biosynthesis I,
tryptophan biosynthesis,
camalexin biosynthesis,
tRNA charging 		0.79 0.47 -0.47 C0257
166 C0149 Mevalonolactone D,L-Mevalonolactone - terpenoid biosynthesis 0.79 0.44 -0.48
167 C0004 β-Alanine - β-Alanine uracil degradation II (reductive),
pantothenate biosynthesis,
beta-alanine biosynthesis II,
beta-alanine biosynthesis I 		0.79 0.43 -0.42 C0004
168 C0104 Glutathione - Glutathione glucosinolate biosynthesis from tryptophan,
glutathione redox reactions I,
glutathione degradation,
gamma-glutamyl cycle (plant pathway),
indole glucosinolate breakdown (active in intact plant cell),
selenate reduction,
glutathione redox reactions II,
glucosinolate biosynthesis from trihomomethionine,
ascorbate glutathione cycle,
glucosinolate biosynthesis from pentahomomethionine,
camalexin biosynthesis,
glucosinolate biosynthesis from homomethionine,
glucosinolate biosynthesis from phenylalanine,
methylglyoxal degradation I,
sulfate reduction II (assimilatory),
glucosinolate biosynthesis from dihomomethionine,
indole glucosinolate breakdown (insect chewing induced),
glutathione biosynthesis,
formaldehyde oxidation II (glutathione-dependent),
glutathione-mediated detoxification II,
glucosinolate biosynthesis from tetrahomomethionine,
glucosinolate biosynthesis from hexahomomethionine,
gamma-glutamyl cycle 		0.78 0.45 -0.43 C0104
169 C0095 Galacturonic acid D-Galacturonic acid D-Galacturonate UDP-D-galacturonate biosynthesis II (from D-galacturonate) 0.78 0.42 -0.47 C0095
170 C0262 UDP-glucuronic acid - UDP-D-glucuronate xylan biosynthesis,
UDP-D-glucuronate biosynthesis (from myo-inositol),
UDP-D-galacturonate biosynthesis I (from UDP-D-glucuronate),
UDP-D-apiose biosynthesis (from UDP-D-glucuronate),
galactose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis 		0.77 0.42 -0.45 C0262
171 C0099 Glucose-1-phosphate α,β-D-Glucose-1-phosphate α-D-Glucose-1-phosphate; β-D-Glucose-1-phosphate galactose degradation I (Leloir pathway) 0.77 0.46 -0.44 C0099
172 C0073 Cysteine L-Cysteine L-Cysteine alanine biosynthesis III,
cysteine biosynthesis I,
gamma-glutamyl cycle (plant pathway),
farnesylcysteine salvage pathway,
molybdenum cofactor biosynthesis,
thiamine biosynthesis II,
cyanide detoxification II,
indole glucosinolate breakdown (insect chewing induced),
glutathione degradation,
glutathione biosynthesis,
molybdenum cofactor biosynthesis II (eukaryotes),
cyanide degradation,
homocysteine and cysteine interconversion,
methionine biosynthesis II,
tRNA charging,
gamma-glutamyl cycle,
coenzyme A biosynthesis 		0.77 0.43 -0.46 C0073
173 C0087 Erythrose-4-phosphate D-Erythrose-4-phosphate D-Erythrose-4-phosphate Rubisco shunt,
pentose phosphate pathway (non-oxidative branch),
chorismate biosynthesis,
Calvin-Benson-Bassham cycle 		0.76 0.41 -0.45 C0087
174 C0075 dGDP - dGDP purine nucleotide metabolism (phosphotransfer and nucleotide modification) 0.75 0.45 -0.43 C0075
175 C0088 FAD - FAD cytokinins degradation,
lysine degradation II,
valine degradation I,
isoleucine degradation I,
flavin biosynthesis I (bacteria and plants) 		0.74 0.46 -0.44 C0088
176 C0056 AMP - AMP PRPP biosynthesis I,
fatty acid biosynthesis (plant mitochondria),
adenine and adenosine salvage VI,
biotin-carboxyl carrier protein assembly,
molybdenum cofactor biosynthesis II (eukaryotes),
gluconeogenesis I,
adenine and adenosine salvage II,
asparagine biosynthesis I,
L-glutamine biosynthesis II (tRNA-dependent),
trans-cinnamoyl-CoA biosynthesis,
IAA degradation V,
ethanol degradation II (cytosol),
arginine biosynthesis I,
IAA degradation IV,
fatty acid activation,
selenate reduction,
IAA biosynthesis VII,
4-hydroxybenzoate biosynthesis V,
tetrapyrrole biosynthesis I,
flavonoid biosynthesis,
indole-3-acetyl-amino acid biosynthesis,
glutamine biosynthesis III,
ethanol degradation IV (peroxisomal),
glycolysis I,
asparagine biosynthesis III (tRNA-dependent),
jasmonoyl-amino acid conjugates biosynthesis I,
molybdenum cofactor biosynthesis,
pyridine nucleotide cycling (plants),
scopoletin biosynthesis,
jasmonic acid biosynthesis,
adenosine nucleotides degradation I,
fatty acid beta-oxidation II (core pathway),
simple coumarins biosynthesis,
sulfate reduction II (assimilatory),
pantothenate biosynthesis,
sporopollenin precursor biosynthesis,
urea cycle,
thiamine biosynthesis II,
starch degradation II,
NAD biosynthesis I (from aspartate),
citrulline-nitric oxide cycle,
beta-alanine biosynthesis II,
arginine biosynthesis II (acetyl cycle),
suberin biosynthesis,
linoleate biosynthesis I (plants),
trans-zeatin biosynthesis,
tetrahydrofolate biosynthesis II,
purine nucleotides de novo biosynthesis II,
phenylpropanoid biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
purine nucleotide metabolism (phosphotransfer and nucleotide modification),
tRNA charging 		0.74 0.46 -0.45 C0056
177 C0062 Betain - - - 0.74 0.47 -0.45
178 C0032 3-Phosphoglyceric acid 3-Phospho-(R)-glyceric acid 3-Phosphoglycerate glycolysis I,
gluconeogenesis I,
Calvin-Benson-Bassham cycle,
sucrose biosynthesis I,
serine biosynthesis,
photorespiration,
Rubisco shunt,
glycolysis IV (plant cytosol) 		0.74 0.44 -0.45 C0032
179 C0140 Lysine L-Lysine L-Lysine lysine degradation II,
tRNA charging,
lysine biosynthesis VI,
lysine degradation I 		0.74 0.46 -0.46 C0140
180 C0186 NAD - NAD+ ammonia assimilation cycle II,
aspartate degradation II,
adenosine nucleotides degradation I,
plant sterol biosynthesis II,
UDP-D-xylose and UDP-D-glucuronate biosynthesis,
NAD biosynthesis I (from aspartate),
ethanol degradation IV (peroxisomal),
abscisic acid biosynthesis,
palmitate biosynthesis II (bacteria and plants),
zeaxanthin biosynthesis,
sucrose degradation to ethanol and lactate (anaerobic),
glutamate degradation IV,
stearate biosynthesis II (plants),
guanosine nucleotides degradation II,
glutamate degradation I,
mannitol degradation II,
glycerol-3-phosphate shuttle,
2-ketoglutarate dehydrogenase complex,
arginine degradation I (arginase pathway),
aerobic respiration (alternative oxidase pathway),
branched-chain alpha-keto acid dehydrogenase complex,
4-aminobutyrate degradation IV,
glycolysis I,
glycine cleavage complex,
lysine degradation II,
fatty acid beta-oxidation II (core pathway),
nitrate reduction II (assimilatory),
TCA cycle variation V (plant),
leucine degradation I,
thiamine biosynthesis II,
acetaldehyde biosynthesis I,
sorbitol degradation I,
glutamine biosynthesis III,
aerobic respiration (cytochrome c),
ethanol degradation I,
ascorbate biosynthesis I (L-galactose pathway),
glycolysis IV (plant cytosol),
benzoate biosynthesis II (CoA-independent, non-beta-oxidative),
siroheme biosynthesis,
TCA cycle variation III (eukaryotic),
isoleucine degradation I,
pyridine nucleotide cycling (plants),
tyrosine biosynthesis I,
gluconeogenesis I,
glycine betaine biosynthesis III (plants),
traumatin and (Z)-3-hexen-1-yl acetate biosynthesis,
NAD/NADH phosphorylation and dephosphorylation,
guanosine nucleotides degradation I,
purine nucleotides de novo biosynthesis II,
acetyl-CoA biosynthesis (from pyruvate),
serine biosynthesis,
photorespiration,
histidine biosynthesis,
glyoxylate cycle,
jasmonic acid biosynthesis,
alanine degradation II (to D-lactate),
a ubiquinone + NADH + H+ -> a ubiquinol + NAD+,
putrescine degradation IV,
brassinosteroid biosynthesis III,
fatty acid elongation -- saturated,
pyruvate fermentation to ethanol II,
beta-alanine biosynthesis II,
4-hydroxybenzoate biosynthesis V,
plant sterol biosynthesis,
urate biosynthesis/inosine 5'-phosphate degradation,
phenylalanine degradation III,
glutamate biosynthesis IV,
leucine biosynthesis,
fatty acid alpha-oxidation,
a ubiquinone + NADH + H+ -> NAD+ + a ubiquinol,
Fe(III)-reduction and Fe(II) transport,
purine nucleotide metabolism (phosphotransfer and nucleotide modification),
phenylethanol biosynthesis,
pyruvate fermentation to lactate,
superpathway of glyoxylate cycle and fatty acid degradation,
fatty acid omega-oxidation,
galactose degradation III,
ethanol degradation II (cytosol),
sucrose biosynthesis I,
valine degradation I,
folate transformations II 		0.73 0.46 -0.45 C0186
181 C0052 Adenosine - Adenosine adenine and adenosine salvage VI,
S-adenosyl-L-methionine cycle II,
cytokinins degradation,
methionine degradation I (to homocysteine),
adenine and adenosine salvage II 		0.72 0.44 -0.44 C0052
182 C0113 Histidinol - Histidinol histidine biosynthesis 0.72 0.43 -0.47 C0113
183 C0053 ADP - ADP phosphatidylcholine biosynthesis I,
mannitol degradation II,
lipid IVA biosynthesis,
stachyose degradation,
Rubisco shunt,
copper transport II,
glycerol degradation IV,
chorismate biosynthesis,
folate polyglutamylation II,
galactose degradation III,
D-myo-inositol (1,4,5)-trisphosphate biosynthesis,
UDP-L-arabinose biosynthesis II (from L-arabinose),
cadmium transport I,
folate polyglutamylation,
coenzyme A biosynthesis,
sulfate activation for sulfonation,
1,4-dihydroxy-2-naphthoate biosynthesis II (plants),
pyrimidine deoxyribonucleotides de novo biosynthesis I,
galactose degradation II,
inosine-5'-phosphate biosynthesis II,
ribose degradation,
acetyl-CoA biosynthesis (from citrate),
inositol pyrophosphates biosynthesis,
fatty acid biosynthesis initiation I,
xylose degradation I,
adenine and adenosine salvage VI,
TCA cycle variation III (eukaryotic),
tetrahydrofolate biosynthesis II,
phosphatidylethanolamine biosynthesis II,
pyridoxal 5'-phosphate salvage pathway,
citrulline biosynthesis,
trans-zeatin biosynthesis,
glutamine biosynthesis I,
arginine biosynthesis II (acetyl cycle),
L-Ndelta-acetylornithine biosynthesis,
mevalonate pathway I,
methionine biosynthesis II,
trehalose degradation II (trehalase),
citrulline degradation,
methionine salvage pathway,
TCA cycle variation V (plant),
chlorophyllide a biosynthesis I,
starch degradation I,
methylerythritol phosphate pathway,
pyridine nucleotide cycling (plants),
ceramide degradation,
biotin-carboxyl carrier protein assembly,
purine nucleotide metabolism (phosphotransfer and nucleotide modification),
UDP-D-galacturonate biosynthesis II (from D-galacturonate),
asparagine biosynthesis III (tRNA-dependent),
superpathway of glyoxylate cycle and fatty acid degradation,
NAD/NADH phosphorylation and dephosphorylation,
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3),
galactose degradation I (Leloir pathway),
uridine-5'-phosphate biosynthesis,
lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3),
sucrose degradation III,
lysine biosynthesis VI,
sphingolipid biosynthesis (plants),
choline biosynthesis I,
GDP-glucose biosynthesis,
photorespiration,
gamma-glutamyl cycle (plant pathway),
5-aminoimidazole ribonucleotide biosynthesis I,
gamma-glutamyl cycle,
thiamine biosynthesis II,
proline biosynthesis III,
glutathione biosynthesis,
folate transformations II,
ornithine biosynthesis,
diphthamide biosynthesis,
S-methyl-5'-thioadenosine degradation I,
starch biosynthesis,
arginine biosynthesis I,
homoserine biosynthesis,
flavin biosynthesis I (bacteria and plants),
sucrose biosynthesis I,
leucine degradation I,
glycolysis I,
pyrimidine ribonucleotides interconversion,
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza),
glycolysis IV (plant cytosol),
Calvin-Benson-Bassham cycle,
UDP-D-glucuronate biosynthesis (from myo-inositol),
guanine and guanosine salvage III,
glutamine biosynthesis III,
L-glutamine biosynthesis II (tRNA-dependent),
GDP-L-fucose biosynthesis II (from L-fucose),
nitrate reduction II (assimilatory),
ammonia assimilation cycle II,
gluconeogenesis I,
threonine biosynthesis from homoserine,
mannose degradation,
urea cycle,
lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3),
biotin biosynthesis II 		0.72 0.46 -0.48 C0053
184 C0261 UDP-glucose - UDP-D-glucose quercetin glucoside biosynthesis (Arabidopsis),
abscisic acid glucose ester biosynthesis,
anthocyanin biosynthesis (delphinidin 3-O-glucoside),
UDP-glucose biosynthesis (from sucrose),
2,4,6-trinitrotoluene degradation,
galactose degradation I (Leloir pathway),
cytokinins-O-glucoside biosynthesis,
trehalose biosynthesis I,
dolichyl-diphosphooligosaccharide biosynthesis,
phenolic malonylglucosides biosynthesis,
callose biosynthesis,
superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside),
glucosinolate biosynthesis from hexahomomethionine,
coniferin metabolism,
glucosinolate biosynthesis from phenylalanine,
xyloglucan biosynthesis,
glucosinolate biosynthesis from pentahomomethionine,
anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside),
glucosinolate biosynthesis from dihomomethionine,
cellulose biosynthesis,
sinapate ester biosynthesis,
superpathway of IAA conjugate biosynthesis,
salicylate glucosides biosynthesis IV,
sucrose biosynthesis I,
glucosinolate biosynthesis from trihomomethionine,
tetrahydrofolate biosynthesis II,
sucrose degradation III,
UDP-D-xylose and UDP-D-glucuronate biosynthesis,
coumarin biosynthesis (via 2-coumarate),
superpathway of sucrose and starch metabolism I (non-photosynthetic tissue),
monolignol glucosides biosynthesis,
glucosinolate biosynthesis from homomethionine,
kaempferol glucoside biosynthesis (Arabidopsis),
salicylate glucosides biosynthesis III,
cytokinins 7-N-glucoside biosynthesis,
galactose degradation III,
cytokinins 9-N-glucoside biosynthesis,
glucosinolate biosynthesis from tryptophan,
UDP-galactose biosynthesis,
salicylate glucosides biosynthesis II,
stachyose degradation,
superpathway of sucrose and starch metabolism II (photosynthetic tissue),
UDP-glucose biosynthesis (from glucose 6-phosphate),
sphingolipid biosynthesis (plants),
glucosinolate biosynthesis from tetrahomomethionine,
galactose degradation II,
UDP-L-rhamnose biosynthesis 		0.72 0.42 -0.44 C0261
185 C0069 Citrulline - Citrulline citrulline-nitric oxide cycle,
citrulline biosynthesis,
nitric oxide biosynthesis I (in plants),
urea cycle,
citrulline degradation,
arginine biosynthesis II (acetyl cycle),
arginine biosynthesis I 		0.71 0.46 -0.42 C0069
186 C0005 β-Fructose-6-phosphate β-D-Fructose-6-phosphate D-Fructose-6-phosphate starch biosynthesis,
Rubisco shunt,
Calvin-Benson-Bassham cycle,
mannitol degradation II,
ascorbate biosynthesis I (L-galactose pathway),
UDP-N-acetyl-D-glucosamine biosynthesis II,
GDP-mannose biosynthesis,
mannose degradation,
sucrose biosynthesis I,
sucrose degradation III,
glycolysis IV (plant cytosol),
pentose phosphate pathway (non-oxidative branch),
glycolysis I,
superpathway of sucrose and starch metabolism II (photosynthetic tissue),
D-mannose degradation,
gluconeogenesis I 		0.7 0.46 -0.45 C0005
187 C0022 1,4-Butanediamine - Putrescine spermine and spermidine degradation III,
putrescine degradation IV,
superpathway of polyamine biosynthesis,
putrescine biosynthesis II,
spermidine biosynthesis I,
putrescine biosynthesis I 		0.7 0.44 -0.46 C0022
188 C0066 Choline - Choline choline biosynthesis III,
phosphatidylcholine biosynthesis I,
choline biosynthesis I,
glycine betaine biosynthesis III (plants),
choline biosynthesis II,
sinapate ester biosynthesis,
phospholipases 		0.68 0.42 -0.42 C0066
189 C0259 Tyramine - Tyramine hydroxycinnamic acid tyramine amides biosynthesis,
suberin biosynthesis 		0.67 0.46 -0.41 C0259
190 C0011 N-Acetyl-glutamic acid N-Acetyl-D,L-glutamic acid N-Acetyl-L-glutamate arginine biosynthesis II (acetyl cycle),
ornithine biosynthesis 		0.67 0.48 -0.42 C0011